• About Us
  • Contact Us
  • Cookie policy (EU)
  • Home
  • Privacy Policy
  • Video
  • Write for us
Today Headline
  • HOME
  • NEWS
    • POLITICS
    • News for today
    • Borisov news
  • FINANCE
    • Business
    • Insurance
  • Video
  • TECHNOLOGY
  • ENTERPRISE
  • LIFESTYLE
    • TRAVEL
    • HEALTH
    • ENTERTAINMENT
  • AUTOMOTIVE
  • SPORTS
  • Travel and Tourism
  • HOME
  • NEWS
    • POLITICS
    • News for today
    • Borisov news
  • FINANCE
    • Business
    • Insurance
  • Video
  • TECHNOLOGY
  • ENTERPRISE
  • LIFESTYLE
    • TRAVEL
    • HEALTH
    • ENTERTAINMENT
  • AUTOMOTIVE
  • SPORTS
  • Travel and Tourism
No Result
View All Result
TodayHeadline
No Result
View All Result

A protein that detects cold and menthol may also be key to migraine headaches

April 11, 2022
in Health
0
A protein that detects cold and menthol may also be key to migraine headaches
0
SHARES
2
VIEWS
Share on FacebookShare on Twitter


migraine

Credit: Pixabay/CC0 Public Domain

Scientists have provided the strongest evidence yet that a protein that enables us to detect the sensation of cold may also be responsible for migraines. The findings appear in the journal Pain.

The findings move TRPM8 into the light as a potential target for new drugs aimed at relieving migraine.

“Our results confirm the importance of TRPM8 in migraines that was suggested by human genome-wide association studies and implicate the protein as a potentially important component of the pathology that leads to migraine. Thus, other scientists or clinicians can now add TRPM8 to their models of migraine and potential targets for treatment,” says David McKemy, professor of biological sciences at USC Dornsife and corresponding author on the study.

  • About 10% of all humans suffer from migraine—nearly 800 million people globally.
  • Those who experience migraine are known as migraineurs.
  • Symptoms include painful headaches as well as nausea, sensitivity to light, sound and sometimes touch and smell.
  • Migraine may also cause aura, including visual effects (shapes, flashes or vision loss), weakness or numbness in the face or body, prickly sensations in an arm or leg, or trouble speaking.

To understand TRPM8’s role in migraine, McKemy and his team studied mice that were genetically engineered to lack TRPM8. They gave the mice either nitroglycerin or a peptide known as CGRP, both of which can induce migraine-like symptoms including spontaneous pain and evoked pain.

  • Spontaneous pain includes the headache arising during a migraine episode.
  • Evoked pain comes from increased sensitivity during migraine, such as when touched or exposed to light.

“We showed that both spontaneous pain and evoked pain that is induced in mice by treatments with nitroglycerin and CGRP was absent in mice genetically modified to not make the TRPM8 protein or lack the nerves that normally contain TRPM8,” McKemy said. “The results show that TRPM8 is necessary for migraine-like pain in mice.”

McKemy and his team also took a pharmacological approach, studying normal mice that had TRPM8 to understand how they react when given nitroglycerin or CGRP.

“We showed that we could treat mice with a drug that blocks TRPM8 function and prevent migraine-like pain,” he said, giving further evidence that TRPM8 is a strong candidate target for new anti-migraine drugs.

The researchers now aim to answer new questions arising from their work, including:

  • How does TRPM8 mediate migraine-like pain at the molecular and cellular level?
  • Are migraineurs predisposed to headaches due to mutations in TRPM8 or is it something in the cellular processes that alter TRPM8 function?
  • Can blocking TRPM8 function in humans with medicines be a method of treatment?

Shape of structure that nerve cells use to sense cold and menthol could be new target for chronic pain and migraine


More information:
Chao Wei et al, Transient receptor potential melastatin 8 (TRPM8) is required for nitroglycerin and calcitonin gene-related peptide induced migraine-like pain behaviors in mice, Pain (2022). DOI: 10.1097/j.pain.0000000000002635

Journal information:
Pain

Provided by
University of Southern California

Citation:
A protein that detects cold and menthol may also be key to migraine headaches (2022, April 11)
retrieved 11 April 2022
from https://medicalxpress.com/news/2022-04-protein-cold-menthol-key-migraine.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Tags: ColddetectsheadacheskeymentholMigraineProtein
Previous Post

MAFS star Domenica Calarco signs deal with celebrity agent

Next Post

Organic semiconductor-based nanoparticles with long-lasting reactive charges

Related Posts

Pina coladas contain as much sugar as EIGHT Krispy Kreme glazed doughnuts
Health

Pina coladas contain as much sugar as EIGHT Krispy Kreme glazed doughnuts

Just one glass of pina...

Read more
What to Look for When Choosing One
Health

‘One Day, You Feel Fantastic, Next Day, You Can’t Move’

Sydney Evans had just returned...

Read more
New research questions previous link between diabetes drugs and bone fractures
Health

New research questions previous link between diabetes drugs and bone fractures

Graphical abstract: Journal of the...

Read more
11 Best Standup Paddleboards of 2022
Health

11 Best Standup Paddleboards of 2022

The sun’s out, the weather’s...

Read more
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 | NEJM – nejm.org
Health

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 | NEJM – nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMoa2118946

Read more
Load More
Next Post
Organic semiconductor-based nanoparticles with long-lasting reactive charges

Organic semiconductor-based nanoparticles with long-lasting reactive charges

  • Trending
  • Comments
  • Latest
Sex/Life fans notice a HUGE editing fail in Adam Demos’ nude shower scene –

Sex/Life fans notice a HUGE editing fail in Adam Demos’ nude shower scene –

Horror as goat gives birth to ‘humanoid kid’ with baby-like face

Gervonta Davis vs Rolando Romero: Weigh-in Results, Odds & Live Stream

Gervonta Davis vs Rolando Romero: Weigh-in Results, Odds & Live Stream

Six times actors really romped in sex scenes that make 365 DNI look tame

Six times actors really romped in sex scenes that make 365 DNI look tame

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

This Memorial Day, Embrace an Attitude of Gratitude to Honor Those Lost

This Memorial Day, Embrace an Attitude of Gratitude to Honor Those Lost

Measuring The Costs And Benefits Of Learning Experiences

Measuring The Costs And Benefits Of Learning Experiences

About Us

Todayheadline the independent news and topics discovery
A home-grown and independent news and topic aggregation . displays breaking news linking to news websites all around the world.

Follow Us

Latest News

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Monaco Grand Prix preview: Leclerc looks to end jinx, three teams fight for pole

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

Soccer Star Andy Carroll CAUGHT IN BED With Another Woman Weeks Before Marrying TOWIE Star Billi Mucklow!

This Memorial Day, Embrace an Attitude of Gratitude to Honor Those Lost

This Memorial Day, Embrace an Attitude of Gratitude to Honor Those Lost

  • Real Estate
  • Education
  • Parenting
  • Cooking
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2021 All rights are reserved Todayheadline

No Result
View All Result
  • Real Estate
  • Education
  • Parenting
  • Cooking
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2021 All rights are reserved Todayheadline

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist

Posting....