For patients with inflammatory bowel disease (IBD), alterations in gut microbiota are associated with health-related quality of life (HRQoL) outcomes, according to a study published online Sept. 29 in The American Journal of Gastroenterology.
R.D. Little, from the University of New South Wales in Australia, and colleagues measured HRQoL and its association with clinical and microbial features in patients with IBD and healthy controls (HCs). A total of 751 participants were included: 305 HCs, 232 with Crohn’s disease (CD), and 214 with ulcerative colitis (UC). Fecal and oral samples, demographics, and Short-Form 36 (SF-36) and the 32-item IBD Questionnaire (IBDQ-32) surveys were obtained at baseline.
The researchers found that HRQoL was lower in patients with IBD versus HCs using the SF-36 (physical component summary score, 51.6 versus 55.7; mental component summary score, 45.1 versus 52.2). Impaired IBD-HRQoL (IBDQ-32 score
In patients with CD and patients with UC, 62 genera were associated with at least one HRQoL measure. Associations between genera and HRQoL measures outweighed microbial associations with clinical and biochemical activity in number and strength.
“We show that alterations in gut microbiota are significantly and consistently associated with general and IBD-specific HRQoL outcomes in IBD,” the authors write.
More information:
R.D. Little et al, Gut microbiota are more strongly associated with impairments in health-related quality of life than disease activity in inflammatory bowel disease, American Journal of Gastroenterology (2025). DOI: 10.14309/ajg.0000000000003773
2025 HealthDay. All rights reserved.
Citation:
Alterations in gut microbiota linked to health-related quality of life outcomes in IBD (2025, October 22)
retrieved 22 October 2025
from https://medicalxpress.com/news/2025-10-gut-microbiota-linked-health-quality.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
For patients with inflammatory bowel disease (IBD), alterations in gut microbiota are associated with health-related quality of life (HRQoL) outcomes, according to a study published online Sept. 29 in The American Journal of Gastroenterology.
R.D. Little, from the University of New South Wales in Australia, and colleagues measured HRQoL and its association with clinical and microbial features in patients with IBD and healthy controls (HCs). A total of 751 participants were included: 305 HCs, 232 with Crohn’s disease (CD), and 214 with ulcerative colitis (UC). Fecal and oral samples, demographics, and Short-Form 36 (SF-36) and the 32-item IBD Questionnaire (IBDQ-32) surveys were obtained at baseline.
The researchers found that HRQoL was lower in patients with IBD versus HCs using the SF-36 (physical component summary score, 51.6 versus 55.7; mental component summary score, 45.1 versus 52.2). Impaired IBD-HRQoL (IBDQ-32 score
In patients with CD and patients with UC, 62 genera were associated with at least one HRQoL measure. Associations between genera and HRQoL measures outweighed microbial associations with clinical and biochemical activity in number and strength.
“We show that alterations in gut microbiota are significantly and consistently associated with general and IBD-specific HRQoL outcomes in IBD,” the authors write.
More information:
R.D. Little et al, Gut microbiota are more strongly associated with impairments in health-related quality of life than disease activity in inflammatory bowel disease, American Journal of Gastroenterology (2025). DOI: 10.14309/ajg.0000000000003773
2025 HealthDay. All rights reserved.
Citation:
Alterations in gut microbiota linked to health-related quality of life outcomes in IBD (2025, October 22)
retrieved 22 October 2025
from https://medicalxpress.com/news/2025-10-gut-microbiota-linked-health-quality.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
