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Home Science & Environment Medical Research

Aluminum exposure from childhood vaccines not linked to increased risk of certain chronic disorders

July 14, 2025
in Medical Research
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A nationwide cohort study of Danish children examined the association between cumulative aluminum exposure from early childhood vaccination and the risk for the development of autoimmune, atopic or allergic, and neurodevelopmental disorders.

The study found no evidence supporting an increased risk for these disorders associated with exposure to early childhood aluminum-adjuvanted vaccines. The findings help close the evidence gap of human data around the association between aluminum-adjuvanted vaccines with adverse events, particularly neurological disorders. The findings are published in Annals of Internal Medicine.

Researchers from the Statens Serum Institut leveraged national changes in the Danish Childhood Vaccination Program over a 24-year period, during which vaccines with varying aluminum content were introduced.

They included 1,224,176 children born in Denmark between 1997 and 2018 and used the Danish nationwide health registries to obtain information on the cumulative aluminum exposure from childhood vaccines administered to each child before age 2 and incident events of 50 different chronic disorders.

Specifically, they examined the development of 36 autoimmune, nine atopic or allergic, and five neurodevelopmental-related disorders. Children were followed from 2 years of age for study outcome events until 31 December 2020, or until they reached age 5, died, or were lost to follow-up.

Cox proportional hazards regression models were used to estimate adjusted hazard ratios representing how much the hazard changed when a child received one additional milligram of aluminum in their vaccines by age two compared to a child who received one milligram less.

The researchers found a hazard ratio for autoimmune outcomes of 0.98 [95%CI 0.94 to 1.02] per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination. The hazard ratio was 0.99 [95%CI 0.98 to 1.01] for atopic or allergic disorders and 0.93 [95%CI 0.90 to 0.97] for neurodevelopmental disorders.

For the specific disorders of autism spectrum disorder and attention-deficit/hyperactivity disorder, the hazard ratios per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination before age two were 0.93 [95%CI 0.89 to 0.97] and 0.90 [95%CI 0.84 to 0.96], respectively.

This nationwide study did not find evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to aluminum-adjuvanted vaccines.

More information:
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study, Annals of Internal Medicine (2025). DOI: 10.7326/ANNALS-25-00997

Provided by
American College of Physicians


Citation:
Aluminum exposure from childhood vaccines not linked to increased risk of certain chronic disorders (2025, July 14)
retrieved 14 July 2025
from https://medicalxpress.com/news/2025-07-aluminum-exposure-childhood-vaccines-linked.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.




childhood vaccine
Credit: Unsplash/CC0 Public Domain

A nationwide cohort study of Danish children examined the association between cumulative aluminum exposure from early childhood vaccination and the risk for the development of autoimmune, atopic or allergic, and neurodevelopmental disorders.

The study found no evidence supporting an increased risk for these disorders associated with exposure to early childhood aluminum-adjuvanted vaccines. The findings help close the evidence gap of human data around the association between aluminum-adjuvanted vaccines with adverse events, particularly neurological disorders. The findings are published in Annals of Internal Medicine.

Researchers from the Statens Serum Institut leveraged national changes in the Danish Childhood Vaccination Program over a 24-year period, during which vaccines with varying aluminum content were introduced.

They included 1,224,176 children born in Denmark between 1997 and 2018 and used the Danish nationwide health registries to obtain information on the cumulative aluminum exposure from childhood vaccines administered to each child before age 2 and incident events of 50 different chronic disorders.

Specifically, they examined the development of 36 autoimmune, nine atopic or allergic, and five neurodevelopmental-related disorders. Children were followed from 2 years of age for study outcome events until 31 December 2020, or until they reached age 5, died, or were lost to follow-up.

Cox proportional hazards regression models were used to estimate adjusted hazard ratios representing how much the hazard changed when a child received one additional milligram of aluminum in their vaccines by age two compared to a child who received one milligram less.

The researchers found a hazard ratio for autoimmune outcomes of 0.98 [95%CI 0.94 to 1.02] per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination. The hazard ratio was 0.99 [95%CI 0.98 to 1.01] for atopic or allergic disorders and 0.93 [95%CI 0.90 to 0.97] for neurodevelopmental disorders.

For the specific disorders of autism spectrum disorder and attention-deficit/hyperactivity disorder, the hazard ratios per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination before age two were 0.93 [95%CI 0.89 to 0.97] and 0.90 [95%CI 0.84 to 0.96], respectively.

This nationwide study did not find evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to aluminum-adjuvanted vaccines.

More information:
Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study, Annals of Internal Medicine (2025). DOI: 10.7326/ANNALS-25-00997

Provided by
American College of Physicians


Citation:
Aluminum exposure from childhood vaccines not linked to increased risk of certain chronic disorders (2025, July 14)
retrieved 14 July 2025
from https://medicalxpress.com/news/2025-07-aluminum-exposure-childhood-vaccines-linked.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



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