It was the teenager who needed a late medical timeout when he slid to chase a Murray drop volley only to rip his shoe – and cause his foot to bleed.
And the Scot sealed the memorable win in just over three hours when he took his first match point with a serve and volley on a second serve.
Crowd favourite Murray, who is appearing here for the first time since 2017, said: “I had my chances in the first set but managed to turn it around. It was a brutal match. Three hours for three sets is a bit much.
US Open champion Emma Raducanu lost her first match but there are still three British men in the singles.
British No.1 Dan Evans will take on No.11 seed Diego Schwartzman while Cam Norrie face No.15 seed Roberto Bautista Agut.
“I am just so happy I am still getting to come out here and play. It is great to have fans back in the stands. I am so happy to get to share my tennis with you all again after four years.”