For patients with hepatitis B virus, alcohol is associated with dose-dependent increased risks for cirrhosis and hepatocellular carcinoma (HCC), according to a review published online Jan. 21 in the Journal of Clinical and Translational Hepatology.
Yin-Ping Wu, from the Qilu University Hospital of Shandong University in Jinan, China, and colleagues pooled data on the incidence of cirrhosis and HCC and developed a dose-dependent model of the effect of alcohol on cirrhosis and HCC. Data was included for 33,272 patients with hepatitis B virus from 45 studies.
The researchers found that the overall pooled odds ratios were 2.27 and 2.61 for cirrhosis and HCC, respectively, among drinkers versus nondrinkers. Compared with low-level drinkers, high-level drinkers had estimated pooled odds ratios of 2.34 and 2.42 for cirrhosis and HCC, respectively. A linear dose-dependent analysis showed that each daily consumption of 12 g of alcohol increased the risks for cirrhosis and HCC by 6.2 and 11.5%, respectively.
“Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner,” the authors write.
More information:
Yin-Ping Wu et al, Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review, Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2024.00379
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Citation:
Dose-dependent link seen for alcohol, cirrhosis, liver cancer in patients with hepatitis B (2025, January 29)
retrieved 29 January 2025
from https://medicalxpress.com/news/2025-01-dose-link-alcohol-cirrhosis-liver.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
For patients with hepatitis B virus, alcohol is associated with dose-dependent increased risks for cirrhosis and hepatocellular carcinoma (HCC), according to a review published online Jan. 21 in the Journal of Clinical and Translational Hepatology.
Yin-Ping Wu, from the Qilu University Hospital of Shandong University in Jinan, China, and colleagues pooled data on the incidence of cirrhosis and HCC and developed a dose-dependent model of the effect of alcohol on cirrhosis and HCC. Data was included for 33,272 patients with hepatitis B virus from 45 studies.
The researchers found that the overall pooled odds ratios were 2.27 and 2.61 for cirrhosis and HCC, respectively, among drinkers versus nondrinkers. Compared with low-level drinkers, high-level drinkers had estimated pooled odds ratios of 2.34 and 2.42 for cirrhosis and HCC, respectively. A linear dose-dependent analysis showed that each daily consumption of 12 g of alcohol increased the risks for cirrhosis and HCC by 6.2 and 11.5%, respectively.
“Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner,” the authors write.
More information:
Yin-Ping Wu et al, Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review, Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2024.00379
2025 HealthDay. All rights reserved.
Citation:
Dose-dependent link seen for alcohol, cirrhosis, liver cancer in patients with hepatitis B (2025, January 29)
retrieved 29 January 2025
from https://medicalxpress.com/news/2025-01-dose-link-alcohol-cirrhosis-liver.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
