For patients with hepatitis B virus, alcohol is associated with dose-dependent increased risks for cirrhosis and hepatocellular carcinoma (HCC), according to a review published online Jan. 21 in the Journal of Clinical and Translational Hepatology.
Yin-Ping Wu, from the Qilu University Hospital of Shandong University in Jinan, China, and colleagues pooled data on the incidence of cirrhosis and HCC and developed a dose-dependent model of the effect of alcohol on cirrhosis and HCC. Data was included for 33,272 patients with hepatitis B virus from 45 studies.
The researchers found that the overall pooled odds ratios were 2.27 and 2.61 for cirrhosis and HCC, respectively, among drinkers versus nondrinkers. Compared with low-level drinkers, high-level drinkers had estimated pooled odds ratios of 2.34 and 2.42 for cirrhosis and HCC, respectively. A linear dose-dependent analysis showed that each daily consumption of 12 g of alcohol increased the risks for cirrhosis and HCC by 6.2 and 11.5%, respectively.
“Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner,” the authors write.
More information:
Yin-Ping Wu et al, Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review, Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2024.00379
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Dose-dependent link seen for alcohol, cirrhosis, liver cancer in patients with hepatitis B (2025, January 29)
retrieved 29 January 2025
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For patients with hepatitis B virus, alcohol is associated with dose-dependent increased risks for cirrhosis and hepatocellular carcinoma (HCC), according to a review published online Jan. 21 in the Journal of Clinical and Translational Hepatology. Yin-Ping Wu, from the Qilu University Hospital of Shandong University in Jinan, China, and colleagues pooled data on the incidence of cirrhosis and HCC and developed a dose-dependent model of the effect of alcohol on cirrhosis and HCC. Data was included for 33,272 patients with hepatitis B virus from 45 studies. The researchers found that the overall pooled odds ratios were 2.27 and 2.61 for cirrhosis and HCC, respectively, among drinkers versus nondrinkers. Compared with low-level drinkers, high-level drinkers had estimated pooled odds ratios of 2.34 and 2.42 for cirrhosis and HCC, respectively. A linear dose-dependent analysis showed that each daily consumption of 12 g of alcohol increased the risks for cirrhosis and HCC by 6.2 and 11.5%, respectively. “Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner,” the authors write. More information: 2025 HealthDay. All rights reserved. Citation: This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
Yin-Ping Wu et al, Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review, Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2024.00379
Dose-dependent link seen for alcohol, cirrhosis, liver cancer in patients with hepatitis B (2025, January 29)
retrieved 29 January 2025
from https://medicalxpress.com/news/2025-01-dose-link-alcohol-cirrhosis-liver.html
part may be reproduced without the written permission. The content is provided for information purposes only.
