A search and rescue operation has been launched after the former Chelsea midfielder was reported missing, according to Turkish publication Star.
Atsu, 31, plays for Super Lig club Hatayspor which is based in the Kahramanaras region – one of the worst areas affected.
Over 1,900 people died and thousands more left injured after the powerful 7.8 magnitude quake, followed by a number of strong aftershocks, hit Turkey and northern Syria.
Several of Atsu’s teammates were reportedly rescued by specialists at their homes after the earthquake struck at 4am local time.
Two players and members of the technical staff were “pulled out of the rubble” during dramatic rescue operations.
Hatayspor’s sporting director Taner Savut has also been reporting missing. A desperate search was said to be under way for both men.
Atsu joined Chelsea from Porto for £3.5million in 2013 but failed to make a single appearance for the Premier League side.
He also had loan spells at Vitesse, Everton, Bournemouth, Malaga and Newcastle.