
The most reliable predictor of an ex-smoker’s relapse isn’t strong urges to smoke or low confidence in the ability to stay off tobacco—it’s weariness with the efforts to remain a non-smoker, according to a new study published in Addiction. Ex-smokers appear to return to smoking most often because they’re exhausted from the constant vigilance needed to remain a non-smoker.
This effect is called psychological cessation fatigue, and its influence on ex-smokers is not affected by how long someone has been an ex-smoker or whether they vape to reduce cravings.
Even after years of not smoking, after withdrawal symptoms and conditioned responses are no longer strong, and even with regular hits of nicotine from vaping, the cumulative mental and emotional cost of sustaining not smoking can become so high that it overwhelms the coping skills and motivation to abstain.
This study followed almost 2,000 adult ex-smokers in Australia, Canada, England, and the United States. Most participants had quit smoking years before the study began. At the start of the study, each participant expressed:
- how tired he or she was from trying to stay quit
- how strong the urge to smoke was in the past 24 hours
- how confident he or she was in remaining an ex-smoker
Two years later, 9.2% of the ex-smokers had begun smoking again. The odds of relapse among ex-smokers with high fatigue were 1.64 times higher than those with low fatigue. In other words, the ex-smokers who were most tired of trying to sustain not smoking had a 64% higher likelihood of relapse than ex-smokers who expressed no cessation fatigue.
High urge to smoke and low confidence with remaining an ex-smoker also predicted smoking relapse, but the predictive strength of cessation fatigue was both stronger and at least partly independent of these other two measures.
Lead author Dr. Hua Yong, of Deakin University in Australia, says, “Smoking is notoriously hard to quit. About 95% of unassisted attempts to quit ultimately end in relapse, and even when evidence-based treatments like nicotine patches are used, relapse rates are still high.
“Our research suggests that ‘tiredness with efforts to remain not smoking’ can be a useful screening tool to catch ex-smokers who are at higher risk of relapse and give them support when they need it. We could incorporate assessment of cessation fatigue in routine health checks and be ready to provide relapse prevention interventions where needed. Ex-smokers might also be advised to seek more help when they begin to experience fatigue.”
More information:
Understanding the Role of Cessation Fatigue in Smoking Relapse: Findings from the International Tobacco Control Four Country Smoking and Vaping Survey., Addiction (2025). DOI: 10.1111/add.70196
Provided by
Society for the Study of Addiction
Citation:
Ex-smokers who relapse may simply be tired of the effort of not smoking (2025, October 16)
retrieved 16 October 2025
from https://medicalxpress.com/news/2025-10-smokers-relapse-simply-effort.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

The most reliable predictor of an ex-smoker’s relapse isn’t strong urges to smoke or low confidence in the ability to stay off tobacco—it’s weariness with the efforts to remain a non-smoker, according to a new study published in Addiction. Ex-smokers appear to return to smoking most often because they’re exhausted from the constant vigilance needed to remain a non-smoker.
This effect is called psychological cessation fatigue, and its influence on ex-smokers is not affected by how long someone has been an ex-smoker or whether they vape to reduce cravings.
Even after years of not smoking, after withdrawal symptoms and conditioned responses are no longer strong, and even with regular hits of nicotine from vaping, the cumulative mental and emotional cost of sustaining not smoking can become so high that it overwhelms the coping skills and motivation to abstain.
This study followed almost 2,000 adult ex-smokers in Australia, Canada, England, and the United States. Most participants had quit smoking years before the study began. At the start of the study, each participant expressed:
- how tired he or she was from trying to stay quit
- how strong the urge to smoke was in the past 24 hours
- how confident he or she was in remaining an ex-smoker
Two years later, 9.2% of the ex-smokers had begun smoking again. The odds of relapse among ex-smokers with high fatigue were 1.64 times higher than those with low fatigue. In other words, the ex-smokers who were most tired of trying to sustain not smoking had a 64% higher likelihood of relapse than ex-smokers who expressed no cessation fatigue.
High urge to smoke and low confidence with remaining an ex-smoker also predicted smoking relapse, but the predictive strength of cessation fatigue was both stronger and at least partly independent of these other two measures.
Lead author Dr. Hua Yong, of Deakin University in Australia, says, “Smoking is notoriously hard to quit. About 95% of unassisted attempts to quit ultimately end in relapse, and even when evidence-based treatments like nicotine patches are used, relapse rates are still high.
“Our research suggests that ‘tiredness with efforts to remain not smoking’ can be a useful screening tool to catch ex-smokers who are at higher risk of relapse and give them support when they need it. We could incorporate assessment of cessation fatigue in routine health checks and be ready to provide relapse prevention interventions where needed. Ex-smokers might also be advised to seek more help when they begin to experience fatigue.”
More information:
Understanding the Role of Cessation Fatigue in Smoking Relapse: Findings from the International Tobacco Control Four Country Smoking and Vaping Survey., Addiction (2025). DOI: 10.1111/add.70196
Provided by
Society for the Study of Addiction
Citation:
Ex-smokers who relapse may simply be tired of the effort of not smoking (2025, October 16)
retrieved 16 October 2025
from https://medicalxpress.com/news/2025-10-smokers-relapse-simply-effort.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.












