• Education
    • Higher Education
    • Scholarships & Grants
    • Online Learning
    • School Reforms
    • Research & Innovation
  • Lifestyle
    • Travel
    • Food & Drink
    • Fashion & Beauty
    • Home & Living
    • Relationships & Family
  • Technology & Startups
    • Software & Apps
    • Startup Success Stories
    • Startups & Innovations
    • Tech Regulations
    • Venture Capital
    • Artificial Intelligence
    • Cybersecurity
    • Emerging Technologies
    • Gadgets & Devices
    • Industry Analysis
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy
Today Headline
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
Today Headline
No Result
View All Result
Home Science & Environment

Innovative microneedle technology for penetration depth control todayheadline

January 9, 2025
in Science & Environment
Reading Time: 6 mins read
A A
0
Innovative microneedle technology for penetration depth control
6
SHARES
13
VIEWS
Share on FacebookShare on Twitter


Over the last decade, significant advances in the biomanufacturing of microneedle-based devices (MN)s have emerged highlighting their potential over a range of therapeutic applications.  However, ensuring that these MNs penetrate just the right depth to work effectively without causing harm has been a persistent challenge. Researchers are now tackling this issue, paving the way for more precise and safer treatments. A new approach to controlling the penetration depth of an array of hollow MNs have been successfully developed by a team led by Dr. Maryam Mobed-Miremadi of Santa Clara University, CA, USA. Incorporation of a stopper above the tip limited penetration to a target depth of 150 µm, ensuring precision within the epidermal layer. This work, published in the journal of Applied Mechanics, uses a stopper mechanism to ensure precise targeting while maintaining structural integrity of the 3D-printed device under mechanical load. 

MNs were fabricated using stereolithography (SLA), leveraging a biocompatible photoresin with a 25–50 µm resolution. Shrinkage was quantitatively assessed post-curing using transmission microscopy and imaging analyses.  Thin sterilized cross-linked alginate hydrogel slabs were used as skin analogs to mimic the biomechanical properties of the epidermis. Mechanical testing on these biocompatible hydrogels confirmed the MNs ability to achieve uniform penetration. Profilometry analyses further validated the efficacy of the stopper in maintaining consistent depth across various tests. Pycnometry was used to measure the density of hydrogel films before and after puncture to confirm mass redistribution versus material loss during microneedle indentation.

Extensive testing of the hydrogel phantoms revealed the MNs ability to withstand forces exceeding those typically required for epidermal penetration. Measurements of peak puncture forces, hardness and viscoelastic properties ensure that the design met the necessary standards for practical applications. The stopper’s role in enhancing uniformity and reducing variability in puncture was a significant finding.

Simulations using COMSOL software were conducted to model stress distributions and deformation during device insertion with the experimentally-determined properties of the phantoms and shrinkage parameters. Density findings were not directly simulated but were informed material property inputs for the computational model. These in silico experiments complemented the empirical results, providing insights into the mechanical performance and areas for potential design optimization. Stress relaxation profiles and insertion force trends closely aligned with experimental results reinforcing the robustness of the design and integrated process for device testing.

This study’s methodology and findings provide a foundation for advancing MN technology in precision medical applications. The researchers aim to refine the process for nozzle-to-nozzle penetration reproducibility and scalability. Design flexibility enabled by adapting the stopper’s dimension to insertion depth originally intended for microencapsulated cell delivery expands the potential use to applications such as transdermal drug delivery and biomarker detection, minimizing discomfort and maximizing therapeutic outcomes.

Journal Reference

Defelippi, K.M.; Kwong, A.Y.S.; Appleget, J.R.; Altay, R.; Matheny, M.B.; Dubus, M.M.; Eribes, L.M.; Mobed-Miremadi, M. “An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles.” Appl. Mech.2024, 5, 233-259. https://doi.org/10.3390/applmech5020015

About the Authors

Celebrating 100 years of Women in Engineering the authors biographies are:

Dr. Maryam Mobed-Miremadi is a Teaching Professor in the Department of Bioengineering at Santa Clara University. Her current research interests include simulation, optimization, and statistical validation across multiscale biomaterials-related platforms, including sustainable energy applications.

Kendall DeFelippi graduated from Santa Clara University in December 2023 with an MS in Bioengineering. In addition to working on medical applications of microneedles (MNs), she has researched microneedle scaling for bioprocessing applications. Kendall currently works as an Associate Scientist at Neurocrine Biosciences in San Diego, CA.

Allyson Kwong is a bioengineering student pursuing a five-year BS/MS degree at Santa Clara University and working as a part-time engineer at Stryker Medical. She continues to research quantitative puncture characterization in soft materials.

Julia Appleget is an Electrical Engineering student pursuing an MS degree at Santa Clara University. As a recipient of the Clare Boothe undergraduate grant, her research in bioengineering focused on leveraging the mechanical and electrical properties of tetrafunctional hydrogel networks in biomedical device and bioenergy applications.

Rana Altay is a PhD student in Dr. Araci’s lab at Santa Clara University. Her research lies at the intersection of microfluidics and wearable technologies. Prior to attending Santa Clara University, she studied Mechatronics Engineering at Sabancı University in Turkey.

Maya Matheny is a first-year MD candidate at the Keck School of Medicine at the University of Southern California. She earned her bachelor’s degree in Bioengineering from Santa Clara University, where she developed an interest in biofabrication. Maya is passionate about advancing healthcare equity and combining technical expertise with compassionate patient care.

Maggie Dubus is a first-year MD student at the University of Colorado School of Medicine. She earned her bachelor’s degree in Bioengineering from Santa Clara University, where she developed her translational research skills. Maggie is committed to integrating translational research with high-quality, compassionate patient care throughout her medical career.

Lily Eribes works as an engineer for Microchip Technology Inc. in Arizona. She earned her bachelor’s degree in Bioengineering from Santa Clara University, where she served as a Healthcare Innovation Fellow and researcher.

You have Successfully Subscribed!

Previous Post

Parallel Universes — Mining and Space (Part 3)

Next Post

How to Build a Solid Go-to-Market Strategy for 2025 todayheadline

Related Posts

heterosexual couple

Something Strange Happens to Your Eyes When You’re Sexually Aroused : ScienceAlert todayheadline

June 4, 2025
3
closeup of the helmet and upper torso of an astronaut in a white spacesuit during an exercise here on earth

Europe stages a moon landing to learn how to photograph the real thing (photos)

June 4, 2025
6
Next Post

How to Build a Solid Go-to-Market Strategy for 2025 todayheadline

  • Trending
  • Comments
  • Latest
Family calls for change after B.C. nurse dies by suicide after attacks on the job

Family calls for change after B.C. nurse dies by suicide after attacks on the job

April 2, 2025
Pioneering 3D printing project shares successes

Product reduces TPH levels to non-hazardous status

November 27, 2024

Hospital Mergers Fail to Deliver Better Care or Lower Costs, Study Finds todayheadline

December 31, 2024

Police ID man who died after Corso Italia fight

December 23, 2024
Harris tells supporters 'never give up' and urges peaceful transfer of power

Harris tells supporters ‘never give up’ and urges peaceful transfer of power

0
Des Moines Man Accused Of Shooting Ex-Girlfriend's Mother

Des Moines Man Accused Of Shooting Ex-Girlfriend’s Mother

0

Trump ‘looks forward’ to White House meeting with Biden

0
Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

0

Pickering: Elderly woman randomly stabbed in Ontario identified

June 4, 2025

International Islamic Trade Finance Corporation (ITFC)’s 2024 Annual Report Highlights Record Trade Support, Empowering Organisation of Islamic Cooperation (OIC) Economies and Expanding Global Impact

June 4, 2025
What happens next in Scott McLaughlin-Tony Kanaan spat?

What happens next in Scott McLaughlin-Tony Kanaan spat?

June 4, 2025
Which players should Chelsea sign? Plus: All you need to know about Estêvão, Essugo, other arrivals

Source: Madrid push to sign River’s Mastantuono

June 4, 2025

Recent News

Pickering: Elderly woman randomly stabbed in Ontario identified

June 4, 2025
3

International Islamic Trade Finance Corporation (ITFC)’s 2024 Annual Report Highlights Record Trade Support, Empowering Organisation of Islamic Cooperation (OIC) Economies and Expanding Global Impact

June 4, 2025
3
What happens next in Scott McLaughlin-Tony Kanaan spat?

What happens next in Scott McLaughlin-Tony Kanaan spat?

June 4, 2025
3
Which players should Chelsea sign? Plus: All you need to know about Estêvão, Essugo, other arrivals

Source: Madrid push to sign River’s Mastantuono

June 4, 2025
2

TodayHeadline is a dynamic news website dedicated to delivering up-to-date and comprehensive news coverage from around the globe.

Follow Us

Browse by Category

  • Africa
  • Asia
  • Basketball
  • Business & Finance
  • Climate Change
  • Crime & Justice
  • Cybersecurity
  • Economic Policies
  • Elections
  • Entertainment
  • Entrepreneurship
  • Environmental Policies
  • Europe
  • Football
  • Gadgets & Devices
  • Health
  • Medical Research
  • Mental Health
  • Middle East
  • Motorsport
  • Olympics
  • Politics
  • Public Health
  • Relationships & Family
  • Science & Environment
  • Software & Apps
  • Space Exploration
  • Sports
  • Stock Market
  • Technology & Startups
  • Tennis
  • Travel
  • Uncategorized
  • Us & Canada
  • Wildlife & Conservation
  • World News

Recent News

Pickering: Elderly woman randomly stabbed in Ontario identified

June 4, 2025

International Islamic Trade Finance Corporation (ITFC)’s 2024 Annual Report Highlights Record Trade Support, Empowering Organisation of Islamic Cooperation (OIC) Economies and Expanding Global Impact

June 4, 2025
  • Education
  • Lifestyle
  • Technology & Startups
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy

© 2024 Todayheadline.co

Welcome Back!

OR

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Business & Finance
  • Corporate News
  • Economic Policies
  • Entrepreneurship
  • Market Trends
  • Crime & Justice
  • Court Cases
  • Criminal Investigations
  • Cybercrime
  • Legal Reforms
  • Policing
  • Education
  • Higher Education
  • Online Learning
  • Entertainment
  • Awards & Festivals
  • Celebrity News
  • Movies
  • Music
  • Health
  • Fitness & Nutrition
  • Medical Breakthroughs
  • Mental Health
  • Pandemic Updates
  • Lifestyle
  • Fashion & Beauty
  • Food & Drink
  • Home & Living
  • Politics
  • Elections
  • Government Policies
  • International Relations
  • Legislative News
  • Political Parties
  • Africa
  • Asia
  • Europe
  • Middle East
  • Artificial Intelligence
  • Cybersecurity
  • Emerging Technologies
  • Gadgets & Devices
  • Industry Analysis
  • Basketball
  • Football
  • Motorsport
  • Olympics
  • Climate Change
  • Environmental Policies
  • Medical Research
  • Science & Environment
  • Space Exploration
  • Wildlife & Conservation
  • Sports
  • Tennis
  • Technology & Startups
  • Software & Apps
  • Startup Success Stories
  • Startups & Innovations
  • Tech Regulations
  • Venture Capital
  • Uncategorized
  • World News
  • Us & Canada
  • Public Health
  • Relationships & Family
  • Travel
  • Research & Innovation
  • Scholarships & Grants
  • School Reforms
  • Stock Market
  • TV & Streaming
  • Advertise with Us
  • Privacy & Policy
  • About us
  • Contact

© 2024 Todayheadline.co