The newly-renovated venue in Water Lane, Holbeck, will host the all-night party on Saturday October 2.
DJs Danny Rampling, Seb Fontaine, Tall Paul and Tall Paul will headline the event, with other house and trance acts performing until 4am.
Cream has been a pioneer of the dance music scene since the early nineties, hosting Creamfields festival in Cheshire and popular Ibiza residencies.
It’s the first Cream night at Mint Warehouse, which has already sold out its opening day and night terrace party on June 21.
The 1,200 capacity venue underwent major renovations just before the pandemic hit before being forced to close.
It now boasts an industrial main room with a Funktion One Eno 7 sound system, as well as the smaller Loft and Boiler Room spaces.
Tickets start from £15 and go on sale on Friday April 30 at 10am here.
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