
A five-year clinical study has revealed that spectacle lenses equipped with highly aspherical lenslets (HAL) can significantly slow the progression of myopia and axial elongation in children. The findings are published in the journal Eye and Vision.
Compared to an extrapolated control group, HAL lenses reduced myopia progression by 1.75 diopters (D) and axial elongation by 0.72 mm, effectively lowering the risk of developing high myopia (−6.00 D or worse) by fourfold. These findings mark a critical advancement in long-term myopia management, offering a safe and non-invasive intervention amid a growing global vision crisis.
With nearly half the world’s population projected to be myopic by 2050, HAL lenses may hold the key to preventing serious complications such as retinal detachment and glaucoma. Myopia, already affecting over 30% of the global population, is on the rise—fueled by lifestyle shifts including increased screen exposure and reduced time spent outdoors. In children, unchecked progression often leads to high myopia, which dramatically raises the risk of irreversible vision impairment.
Current interventions—such as atropine eye drops and specially designed contact lenses—face limitations: long-term data is scarce, accessibility remains uneven, and ethical constraints restrict the use of untreated control groups in pediatric trials. This underscores an urgent need for scalable, evidence-based solutions that can safely curb the progression of myopia from an early age.
In the study, a team from Wenzhou Medical University’s Eye Hospital reported five-year outcomes from children using highly aspherical lenslets (HAL) lenses. The study included 43 children and employed an innovative extrapolated control model to navigate the ethical challenges of long-term pediatric trials.
The results were compelling: myopia progression in the HAL group was −1.27 D, versus −3.03 D in controls. Axial elongation, a key marker of myopia severity, was 0.67 mm with HAL lenses versus 1.40 mm in the control group. This is among the first studies to robustly demonstrate the long-term efficacy of optical interventions for myopia control.
Conducted as a five-year randomized trial, the study followed 43 children aged 8 to 13 who wore HAL spectacles, tracking their outcomes against an extrapolated control group informed by historical data. HAL lenses slowed myopia progression by 58%, and axial elongation by 52%. Strikingly, only 9% of children in the HAL group developed high myopia, compared to 38% in the control cohort—a fourfold reduction in risk.
The extrapolated control model, carefully validated against real-world trial data, offered a rigorous yet ethical solution for long-term pediatric research. Notably, the slowing of myopia progression became more pronounced over time, hinting at cumulative effects. Younger children showed stronger responses, consistent with age-related trends in myopia development. Safety profiles were strong, with no reported adverse effects such as dizziness or blurred vision.
While the study’s modest sample size and reliance on modeled controls beyond two years are noted limitations, its alignment with independent studies—such as the LAMP trial on low-dose atropine—reinforces its credibility. HAL lenses stand out as a practical, effective and safe long-term intervention for managing childhood myopia.
“Our results confirm HAL lenses as a viable long-term option for myopia control,” said Dr. Jinhua Bao, co-lead author of the study. “While larger trials are warranted, this work provides a valuable framework for ethical, long-term pediatric eye care research.”
Myopia expert Mark Bullimore, who was not involved in the study, commented, “The extrapolated control design is a novel approach. For real-world implementation, it will be important to assess the cost-effectiveness of HAL lenses in various health care settings.”
With their non-invasive design and ease of integration into standard vision care, HAL lenses could reshape public health strategies targeting myopia, particularly in high-incidence regions such as Asia. Unlike pharmacologic or contact lens alternatives, HAL lenses offer scalability without the same barriers to use. Moreover, this study sets a new precedent for employing modeled control groups in long-term pediatric trials.
Looking ahead, researchers aim to explore the synergy between HAL lenses and other interventions—like increased outdoor activity—as well as real-world adherence patterns. As myopia prevalence continues to climb, solutions like HAL lenses may play a pivotal role in alleviating the long-term health and economic burdens of high myopia.
More information:
Xue Li et al, Myopia control efficacy of spectacle lenses with highly aspherical lenslets: results of a 5-year follow-up study, Eye and Vision (2025). DOI: 10.1186/s40662-025-00427-3
Provided by
Wenzhou Medical University
Citation:
Long-term data support aspherical lenslets as effective myopia control in kids (2025, April 3)
retrieved 3 April 2025
from https://medicalxpress.com/news/2025-04-term-aspherical-lenslets-effective-myopia.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

A five-year clinical study has revealed that spectacle lenses equipped with highly aspherical lenslets (HAL) can significantly slow the progression of myopia and axial elongation in children. The findings are published in the journal Eye and Vision.
Compared to an extrapolated control group, HAL lenses reduced myopia progression by 1.75 diopters (D) and axial elongation by 0.72 mm, effectively lowering the risk of developing high myopia (−6.00 D or worse) by fourfold. These findings mark a critical advancement in long-term myopia management, offering a safe and non-invasive intervention amid a growing global vision crisis.
With nearly half the world’s population projected to be myopic by 2050, HAL lenses may hold the key to preventing serious complications such as retinal detachment and glaucoma. Myopia, already affecting over 30% of the global population, is on the rise—fueled by lifestyle shifts including increased screen exposure and reduced time spent outdoors. In children, unchecked progression often leads to high myopia, which dramatically raises the risk of irreversible vision impairment.
Current interventions—such as atropine eye drops and specially designed contact lenses—face limitations: long-term data is scarce, accessibility remains uneven, and ethical constraints restrict the use of untreated control groups in pediatric trials. This underscores an urgent need for scalable, evidence-based solutions that can safely curb the progression of myopia from an early age.
In the study, a team from Wenzhou Medical University’s Eye Hospital reported five-year outcomes from children using highly aspherical lenslets (HAL) lenses. The study included 43 children and employed an innovative extrapolated control model to navigate the ethical challenges of long-term pediatric trials.
The results were compelling: myopia progression in the HAL group was −1.27 D, versus −3.03 D in controls. Axial elongation, a key marker of myopia severity, was 0.67 mm with HAL lenses versus 1.40 mm in the control group. This is among the first studies to robustly demonstrate the long-term efficacy of optical interventions for myopia control.
Conducted as a five-year randomized trial, the study followed 43 children aged 8 to 13 who wore HAL spectacles, tracking their outcomes against an extrapolated control group informed by historical data. HAL lenses slowed myopia progression by 58%, and axial elongation by 52%. Strikingly, only 9% of children in the HAL group developed high myopia, compared to 38% in the control cohort—a fourfold reduction in risk.
The extrapolated control model, carefully validated against real-world trial data, offered a rigorous yet ethical solution for long-term pediatric research. Notably, the slowing of myopia progression became more pronounced over time, hinting at cumulative effects. Younger children showed stronger responses, consistent with age-related trends in myopia development. Safety profiles were strong, with no reported adverse effects such as dizziness or blurred vision.
While the study’s modest sample size and reliance on modeled controls beyond two years are noted limitations, its alignment with independent studies—such as the LAMP trial on low-dose atropine—reinforces its credibility. HAL lenses stand out as a practical, effective and safe long-term intervention for managing childhood myopia.
“Our results confirm HAL lenses as a viable long-term option for myopia control,” said Dr. Jinhua Bao, co-lead author of the study. “While larger trials are warranted, this work provides a valuable framework for ethical, long-term pediatric eye care research.”
Myopia expert Mark Bullimore, who was not involved in the study, commented, “The extrapolated control design is a novel approach. For real-world implementation, it will be important to assess the cost-effectiveness of HAL lenses in various health care settings.”
With their non-invasive design and ease of integration into standard vision care, HAL lenses could reshape public health strategies targeting myopia, particularly in high-incidence regions such as Asia. Unlike pharmacologic or contact lens alternatives, HAL lenses offer scalability without the same barriers to use. Moreover, this study sets a new precedent for employing modeled control groups in long-term pediatric trials.
Looking ahead, researchers aim to explore the synergy between HAL lenses and other interventions—like increased outdoor activity—as well as real-world adherence patterns. As myopia prevalence continues to climb, solutions like HAL lenses may play a pivotal role in alleviating the long-term health and economic burdens of high myopia.
More information:
Xue Li et al, Myopia control efficacy of spectacle lenses with highly aspherical lenslets: results of a 5-year follow-up study, Eye and Vision (2025). DOI: 10.1186/s40662-025-00427-3
Provided by
Wenzhou Medical University
Citation:
Long-term data support aspherical lenslets as effective myopia control in kids (2025, April 3)
retrieved 3 April 2025
from https://medicalxpress.com/news/2025-04-term-aspherical-lenslets-effective-myopia.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.