• About Us
  • Contact Us
  • today headline
  • Write for us
Today Headline
No Result
View All Result
  • breaking news today
    • Politics news
    • Sports
    • Science News & Society
  • Entertainment News
    • Movie
    • Gaming
  • Technology News
    • Automotive
  • Health News
    • Lifestyle
    • Insurance
  • Finance News
    • Money
  • Enterprise
  • Contact Us
  • breaking news today
    • Politics news
    • Sports
    • Science News & Society
  • Entertainment News
    • Movie
    • Gaming
  • Technology News
    • Automotive
  • Health News
    • Lifestyle
    • Insurance
  • Finance News
    • Money
  • Enterprise
  • Contact Us
No Result
View All Result
TodayHeadline
No Result
View All Result

Medication benefits patients with Huntington’s disease-associated chorea

April 14, 2022
in Health News
Reading Time: 3 mins read
medication benefits pa - TodayHeadline


Medication benefits patients with Huntington’s disease-associated chorea

Erin Furr Stimming, MD, professor of neurology with McGovern Medical School at UTHealth Houston and director of the Huntington’s Disease Society of America Center of Excellence at UTHealth Houston Neurosciences. Credit: UTHealth Houston

A new drug has proven beneficial in treating a movement disorder commonly associated with Huntington’s disease, according to a recent international study led by UTHealth Houston researcher Erin Furr Stimming, MD, who served as principal investigator on behalf of the KINECT-HD Huntington Study Group.

Furr Stimming, professor of neurology with McGovern Medical School at UTHealth Houston, presented findings from the Phase III, randomized, double-blind, placebo-controlled KINECT-HD study for the first time last week at the American Academy of Neurology 2022 Annual Meeting in Seattle, Washington.

She reported that valbenazine, a selective vesicular monamine transporter 2 (VMAT2) inhibitor that is not yet approved by the U.S. Food and Drug Administration specifically for Huntington’s disease, was safe and effective when given as a once-daily treatment for chorea in patients with Huntington’s disease. Chorea is an involuntary, irregular movement, and the cardinal motor feature in Huntington’s disease.

“We are thrilled this study yielded positive results. We saw a statistically significant decrease in Huntington’s disease-related chorea in patients taking valbenazine versus the placebo,” said Furr Stimming, who is also director of the Huntington’s Disease Society of America Center of Excellence at UTHealth Houston Neurosciences. “While chorea is not the only symptom our Huntington’s disease patients experience, it can be quite problematic and can contribute to impairment in day-to-day activities like eating and drinking, and can even lead to frequent falls.”

Interestingly, a majority of people with chorea do not receive a medication intended for the symptom, according to a separate abstract also presented by Furr-Stimming, which retrospectively analyzed data from the Enroll-HD dataset, a worldwide observational study that includes more than 20,000 participants in four continents. Chorea was documented in nearly 97% of participants; however, only 36% of these participants were prescribed medications for chorea, despite the availability of FDA-approved medications, such as VMAT2 inhibitors and off-label medications like antipsychotics and benzodiazepines.

Furr Stimming said continued research is needed to better understand optimal treatment patterns for chorea in patients with Huntington’s disease.

“We do not yet have a disease-modifying therapy for Huntington’s disease, and therefore, we must continue to focus on optimizing symptomatic treatments for the motor and nonmotor symptoms of this disease,” she said.

Huntington’s disease is a rare, inherited disease that typically begins in a person’s 30s or 40s, causing nerve cells in the brain to break down over time. About 40,000 Americans have the fatal disease, while another 200,000 are at risk for inheriting the disease. No cure exists, but medications and physical, speech, and occupational therapy can help manage symptoms.


Chorea reduced by deutetrabenazine in study


More information:
Longitudinal Treatment Patterns for Chorea in Patients with Huntington Disease: Data from Enroll-HD. index.mirasmart.com/aan2022/PD … /AAN2022-001626.html

Provided by
University of Texas Health Science Center at Houston

Citation:
Medication benefits patients with Huntington’s disease-associated chorea (2022, April 14)
retrieved 14 April 2022
from https://medicalxpress.com/news/2022-04-medication-benefits-patients-huntington-disease-associated.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

  • Trending
  • Comments
  • Latest
1675184756 og image 1200 29b2bfe1a595477db6826bd2126c63ac2091efb7ec76347a8e7f81ba17e3de6c - TodayHeadline

NXP Semiconductors N.V. (NXPI) Q4 2022 Earnings Call Transcript

High blood pressure A heart app prescribes musical therapy - TodayHeadline

High blood pressure? A heart app prescribes musical therapy

3maukbWixrF4WhGwvLDA9d 1200 80 - TodayHeadline

Ultra-rare ‘rainbow clouds’ light up the Arctic Circle like auroras in stunning new photos

lil wayne welcome to tha carter tour dates 1200x675 - TodayHeadline

Lil Wayne Announces ‘Welcome To Tha Carter’ Tour

PopularStories

1675184756 og image 1200 29b2bfe1a595477db6826bd2126c63ac2091efb7ec76347a8e7f81ba17e3de6c - TodayHeadline
Business news

NXP Semiconductors N.V. (NXPI) Q4 2022 Earnings Call Transcript

High blood pressure A heart app prescribes musical therapy - TodayHeadline
Technology News

High blood pressure? A heart app prescribes musical therapy

3maukbWixrF4WhGwvLDA9d 1200 80 - TodayHeadline
Science News & Society

Ultra-rare ‘rainbow clouds’ light up the Arctic Circle like auroras in stunning new photos

lil wayne welcome to tha carter tour dates 1200x675 - TodayHeadline
Entertainment News

Lil Wayne Announces ‘Welcome To Tha Carter’ Tour

About Us

Todayheadline the independent news and topics discovery
A home-grown and independent news and topic aggregation . displays breaking news linking to news websites all around the world.

Follow Us

Latest News

1675184756 og image 1200 29b2bfe1a595477db6826bd2126c63ac2091efb7ec76347a8e7f81ba17e3de6c - TodayHeadline

NXP Semiconductors N.V. (NXPI) Q4 2022 Earnings Call Transcript

High blood pressure A heart app prescribes musical therapy - TodayHeadline

High blood pressure? A heart app prescribes musical therapy

3maukbWixrF4WhGwvLDA9d 1200 80 - TodayHeadline

Ultra-rare ‘rainbow clouds’ light up the Arctic Circle like auroras in stunning new photos

1675184756 og image 1200 29b2bfe1a595477db6826bd2126c63ac2091efb7ec76347a8e7f81ba17e3de6c - TodayHeadline

NXP Semiconductors N.V. (NXPI) Q4 2022 Earnings Call Transcript

High blood pressure A heart app prescribes musical therapy - TodayHeadline

High blood pressure? A heart app prescribes musical therapy

3maukbWixrF4WhGwvLDA9d 1200 80 - TodayHeadline

Ultra-rare ‘rainbow clouds’ light up the Arctic Circle like auroras in stunning new photos

  • Real Estate
  • Parenting
  • Cooking
  • NFL Games On TV Today
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2023 All rights are reserved Today headline

No Result
View All Result
  • Real Estate
  • Parenting
  • Cooking
  • NFL Games On TV Today
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2023 All rights are reserved Today headline

This website uses cookies. By continuing to use this website you are giving consent to cookies being used. Visit our Privacy and Cookie Policy.