Two Michigan children are suspected to have had a rare form of hepatitis that the Centers for Disease Control and Prevention is investigating nationwide, state officials confirmed Friday.
One of the cases was from Oakland County and the other was in Detroit, said Lynn Sutfin, a spokeswoman for the Michigan Department of Health and Human Services.
The department has provided the data to the CDC as part of the federal agency’s recent Health Alert Network advisory to notify clinicians and authorities of children identified with hepatitis and adenovirus infection, she said in an email.
“MDHHS is working with clinicians across the state to gather data on children under 10 years of age who have an unknown etiology for their hepatitis since October 1, 2021,” Sutfin wrote. “MDHHS will continue to provide this information to the CDC as they conduct their investigation.”
Other details were not immediately available.
About two dozen states reported suspected cases after the CDC issued the call last month for doctors to watch for surprising cases of hepatitis.
U.S. health officials have been probing more than 100 possible cases in children, including five deaths.
The cases date back to late October in children under 10. So far, only nine cases in Alabama have been confirmed.
“We are casting a wide net to broaden our understanding,” the CDC’s Dr. Jay Butler said Friday.
What’s causing the illnesses isn’t clear. Adenovirus was detected in half the children, “but we do not know if it is the cause,” he said.
There are dozens of adenoviruses, many of them associated with cold-like symptoms, fever, sore throat and pink eye. But some versions can trigger other problems, including inflammation in the stomach and intestines. Officials are exploring a link to one particular version that’s normally associated with gut inflammation.
U.S. health officials haven’t seen evidence of an unusually large wave of adenovirus infections, although many doctors don’t usually test for it.
This week, the World Health Organization officials said they had reports of almost 300 probable cases in 20 countries.
In the U.S., most of the children were toddlers, nearly all were hospitalized and eight received liver transplants
“It’s still a very rare occurrence,” Butler said. “A majority of these cases have recovered and recovered fully.”
The mystery goes back to November when Alabama health officials began looking into the first of nine cases of severe hepatitis in children in that state. None tested positive for the viruses that commonly cause hepatitis. However, testing was positive for adenovirus.
Butler said none of the Alabama children were vaccinated against COVID-19. That has been ruled out as a possible cause, “and we hope this information helps clarify some of the speculation circulating online.”
Symptoms of hepatitis, or inflammation of the liver, include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, light-colored stools, joint pain and jaundice.
In addition to Alabama and Michigan, the states reporting suspected cases include California, Colorado, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Louisiana, Minnesota, Missouri, North Carolina, North Dakota, Nebraska, New York, Ohio, Pennsylvania, Tennessee, Texas, Washington, Wisconsin.
Puerto Rico also reported at least one case.