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Home Science & Environment Medical Research

New guidelines for managing blood cancers in pregnancy

January 3, 2025
in Medical Research
Reading Time: 4 mins read
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Credit: Pixabay/CC0 Public Domain

A new set of guidelines has been developed to assist with the diagnosis and expert management of serious blood cancers in pregnancy.

About 12.5 pregnancies per 100,000 are affected by blood cancers such as acute leukemia and aggressive lymphomas, and their incidence has been rising.

Between 1994 and 2013, they increased by 2.7% a year, due to factors including women having children later, improved diagnostic techniques, and increased health system engagement.

An Australian working group has published a new position statement in Lancet Hematology, based on current evidence and expert consensus.

It forms a practical guide for doctors, including recommendations for diagnosis and staging, imaging safety in pregnancy, therapy in pregnancy incorporating a multidisciplinary approach, supportive care, oncofertility, and pregnancy and birth management.

Lead author Dr. Georgia Mills from Macquarie Medical School says a cancer diagnosis in pregnancy is incredibly distressing for a patient and her family.

“But on top of this, women can experience treatment delays, inaccurate information and communication breakdowns, all of which increases the worry associated with a cancer diagnosis and fears for their unborn baby,” she says.

“Patients have also described a lack of sensitivity about fertility preservation, breastfeeding, medication risks to the unborn baby, and a lack of information and support groups.

“We want women and their babies to experience the best possible health outcomes, not delayed or denied care.”

Senior author Dr. Gisele Kidson-Gerber says taking a multidisciplinary approach was of paramount importance in preparing the guidelines.

“Blood cancers in pregnancy present unique therapeutic challenges, yet there were no clinical guidelines for diagnosis or management,” she says.

“As clinicians, we have to balance the need for optimal treatment for the mother with the safety and well-being of the unborn child.

“Most treatments are possible during pregnancy, including many forms of chemotherapy, but this is not what patients expect.”

The guidelines were drafted using co-design principles, with a patient representative on the working group to ensure patient concerns were well understood.

Victoria Bilsland was diagnosed with stage 4B nodular-predominant Hodgkins lymphoma when she was 17 weeks pregnant.

But with her symptoms repeatedly dismissed as pregnancy pain or possible infection, just getting a diagnosis was a struggle that led her to lose faith in doctors.

“I was told I ‘needed spinal surgery’ and to ‘consider termination,’ and when I declined termination as we still didn’t know the extent of the cancer, I was advised to ‘think logically,'” she says.

“I was offered to terminate my pregnancy on multiple occasions, but I had no information about the risks to me or my baby, or knowledge of what stage the cancer was or even where it was.

“How could I make an impossible decision without information? And why could no one provide me with information regarding cancer and pregnancy?

“The process was a rollercoaster of trauma, depression and anxiety.”

Eventually put into the care of a specialist team experienced in managing hematological cancers in pregnancy, she received appropriate treatment and delivered a healthy son at 32 weeks.

She hopes the new guidelines will help other doctors to make the same decision in a timely way, putting the patient first and reducing potential trauma.

The guidelines have been endorsed by the councils of the Society of Obstetric Medicine of Australia and New Zealand and the Hematology Society of Australia and New Zealand.

More information:
Position statement on the diagnosis and management of acute leukemia and aggressive lymphomas in pregnancy Lancet Haematology (2024). DOI: 10.1016/S2352-3026(24)00309-0

Provided by
Macquarie University


This content was originally published on The Macquarie University Lighthouse.

Citation:
New guidelines for managing blood cancers in pregnancy (2025, January 3)
retrieved 3 January 2025
from https://medicalxpress.com/news/2024-12-guidelines-blood-cancers-pregnancy.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



pregnancy
Credit: Pixabay/CC0 Public Domain

A new set of guidelines has been developed to assist with the diagnosis and expert management of serious blood cancers in pregnancy.

About 12.5 pregnancies per 100,000 are affected by blood cancers such as acute leukemia and aggressive lymphomas, and their incidence has been rising.

Between 1994 and 2013, they increased by 2.7% a year, due to factors including women having children later, improved diagnostic techniques, and increased health system engagement.

An Australian working group has published a new position statement in Lancet Hematology, based on current evidence and expert consensus.

It forms a practical guide for doctors, including recommendations for diagnosis and staging, imaging safety in pregnancy, therapy in pregnancy incorporating a multidisciplinary approach, supportive care, oncofertility, and pregnancy and birth management.

Lead author Dr. Georgia Mills from Macquarie Medical School says a cancer diagnosis in pregnancy is incredibly distressing for a patient and her family.

“But on top of this, women can experience treatment delays, inaccurate information and communication breakdowns, all of which increases the worry associated with a cancer diagnosis and fears for their unborn baby,” she says.

“Patients have also described a lack of sensitivity about fertility preservation, breastfeeding, medication risks to the unborn baby, and a lack of information and support groups.

“We want women and their babies to experience the best possible health outcomes, not delayed or denied care.”

Senior author Dr. Gisele Kidson-Gerber says taking a multidisciplinary approach was of paramount importance in preparing the guidelines.

“Blood cancers in pregnancy present unique therapeutic challenges, yet there were no clinical guidelines for diagnosis or management,” she says.

“As clinicians, we have to balance the need for optimal treatment for the mother with the safety and well-being of the unborn child.

“Most treatments are possible during pregnancy, including many forms of chemotherapy, but this is not what patients expect.”

The guidelines were drafted using co-design principles, with a patient representative on the working group to ensure patient concerns were well understood.

Victoria Bilsland was diagnosed with stage 4B nodular-predominant Hodgkins lymphoma when she was 17 weeks pregnant.

But with her symptoms repeatedly dismissed as pregnancy pain or possible infection, just getting a diagnosis was a struggle that led her to lose faith in doctors.

“I was told I ‘needed spinal surgery’ and to ‘consider termination,’ and when I declined termination as we still didn’t know the extent of the cancer, I was advised to ‘think logically,'” she says.

“I was offered to terminate my pregnancy on multiple occasions, but I had no information about the risks to me or my baby, or knowledge of what stage the cancer was or even where it was.

“How could I make an impossible decision without information? And why could no one provide me with information regarding cancer and pregnancy?

“The process was a rollercoaster of trauma, depression and anxiety.”

Eventually put into the care of a specialist team experienced in managing hematological cancers in pregnancy, she received appropriate treatment and delivered a healthy son at 32 weeks.

She hopes the new guidelines will help other doctors to make the same decision in a timely way, putting the patient first and reducing potential trauma.

The guidelines have been endorsed by the councils of the Society of Obstetric Medicine of Australia and New Zealand and the Hematology Society of Australia and New Zealand.

More information:
Position statement on the diagnosis and management of acute leukemia and aggressive lymphomas in pregnancy Lancet Haematology (2024). DOI: 10.1016/S2352-3026(24)00309-0

Provided by
Macquarie University


This content was originally published on The Macquarie University Lighthouse.

Citation:
New guidelines for managing blood cancers in pregnancy (2025, January 3)
retrieved 3 January 2025
from https://medicalxpress.com/news/2024-12-guidelines-blood-cancers-pregnancy.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


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