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Home Science & Environment Medical Research

Oral glucose-lowering agents are potential alternatives to insulin for gestational diabetes

January 9, 2025
in Medical Research
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Oral glucose-lowering agents potential alternatives to insulin for gestational diabetes

With respect to the proportion of infants born large for gestational age, treatment of gestational diabetes with metformin and glyburide, if needed, does not meet the criteria for noninferiority versus insulin, according to a study published in the Journal of the American Medical Association.

Doortje Rademaker, M.D., from the Amsterdam University Medical Center, and colleagues examined whether a treatment strategy of oral glucose-lowering agents is noninferior to insulin for prevention of large-for-gestational-age infants in a randomized trial conducted at 25 Dutch centers.

In total, 820 individuals with gestational diabetes and singleton pregnancies between 16 and 34 weeks of gestation, with insufficient glycemic control after two weeks of dietary changes, were randomly assigned to receive metformin or insulin (409 and 411 participants, respectively). Glyburide was added to metformin, and if needed to achieve glucose targets, insulin was then substituted for glyburide.

Overall, 79% of the participants randomly assigned to oral agents maintained glycemic control without insulin. The researchers found that 23.9 and 19.9% of infants were large for gestational age with oral agents and insulin, respectively (absolute risk difference, 4.0%; 95% confidence interval, −1.7 to 9.8%; P = 0.09 for noninferiority), with the confidence interval exceeding the absolute noninferiority margin of 8%.

“These findings contribute to existing trial data regarding the use of metformin and glyburide as alternatives for insulin to manage gestational diabetes,” the authors write.

More information:
Doortje Rademaker et al, Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes, JAMA (2025). DOI: 10.1001/jama.2024.23410

Camille E. Powe, For Gestational Diabetes Pharmacotherapy, Insulin Reigns Supreme, JAMA (2025). DOI: 10.1001/jama.2024.27148

2025 HealthDay. All rights reserved.

Citation:
Oral glucose-lowering agents are potential alternatives to insulin for gestational diabetes (2025, January 9)
retrieved 9 January 2025
from https://medicalxpress.com/news/2025-01-oral-glucose-lowering-agents-potential.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Oral glucose-lowering agents potential alternatives to insulin for gestational diabetes

With respect to the proportion of infants born large for gestational age, treatment of gestational diabetes with metformin and glyburide, if needed, does not meet the criteria for noninferiority versus insulin, according to a study published in the Journal of the American Medical Association.

Doortje Rademaker, M.D., from the Amsterdam University Medical Center, and colleagues examined whether a treatment strategy of oral glucose-lowering agents is noninferior to insulin for prevention of large-for-gestational-age infants in a randomized trial conducted at 25 Dutch centers.

In total, 820 individuals with gestational diabetes and singleton pregnancies between 16 and 34 weeks of gestation, with insufficient glycemic control after two weeks of dietary changes, were randomly assigned to receive metformin or insulin (409 and 411 participants, respectively). Glyburide was added to metformin, and if needed to achieve glucose targets, insulin was then substituted for glyburide.

Overall, 79% of the participants randomly assigned to oral agents maintained glycemic control without insulin. The researchers found that 23.9 and 19.9% of infants were large for gestational age with oral agents and insulin, respectively (absolute risk difference, 4.0%; 95% confidence interval, −1.7 to 9.8%; P = 0.09 for noninferiority), with the confidence interval exceeding the absolute noninferiority margin of 8%.

“These findings contribute to existing trial data regarding the use of metformin and glyburide as alternatives for insulin to manage gestational diabetes,” the authors write.

More information:
Doortje Rademaker et al, Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes, JAMA (2025). DOI: 10.1001/jama.2024.23410

Camille E. Powe, For Gestational Diabetes Pharmacotherapy, Insulin Reigns Supreme, JAMA (2025). DOI: 10.1001/jama.2024.27148

2025 HealthDay. All rights reserved.

Citation:
Oral glucose-lowering agents are potential alternatives to insulin for gestational diabetes (2025, January 9)
retrieved 9 January 2025
from https://medicalxpress.com/news/2025-01-oral-glucose-lowering-agents-potential.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


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