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Oxford-AstraZeneca vaccine shows promise in elderly, trial results by Christmas

3 years ago
in breaking news today, Health News
Reading Time: 7 mins read


Oxford University and AstraZeneca’s potential COVID-19 vaccine produced a strong immune response in older adults, newly published data has showed, with researchers expecting to release late-stage trial results by Christmas.

Key points:

  • Late stage Oxford-AstraZeneca trials have shown it develops antibody and T-cell responses in elderly patients
  • Rival drugmakers Pfizer-BioNTech and Moderna have recently pushed ahead in the race for a COVID vaccine
  • Researchers report no serious side effects from the Oxford-AstraZeneca vaccine

The data, reported in part last month but published in full in The Lancet medical journal on Thursday, suggest that those aged over 70, who are at higher risk of serious illness and death from COVID-19, could build robust immunity.

“The robust antibody and T-cell responses seen in older people in our study are encouraging,” said Maheshi Ramasamy, a consultant and co-lead investigator at the Oxford Vaccine Group.

“We hope that this means our vaccine will help to protect some of the most vulnerable people in society, but further research will be needed before we can be sure.”

Catch up on the main COVID-19 news from November 19 with our coronavirus blog.

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Experts say the Government’s move to lock in four different COVID-19 vaccines is “clever”, but warn of significant hurdles to overcome before they can be distributed across the country.

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Late-stage, or phase-three, trials are ongoing to confirm the findings, researchers said, and to test whether the vaccine protects against infection with SARS-CoV-2 in a broad range of people, including people with underlying health conditions.

Results of those trials should definitely be known by Christmas, the Oxford Vaccine Group’s director Andrew Pollard said, adding it was too early to know whether and how well the vaccine works in preventing the COVID-19 disease.

“We’re still waiting to get to the point where we can do the analysis to just work out how well the vaccine can protect people, and we’re getting ever closer to that,” he told journalists.

“We are optimistic that we’ll be able to do that before Christmas, and obviously we’ll share that with you as soon as we can at that point.”

Earlier this month, Australian manufacturer CSL kicked off production of 30 million doses of the Oxford-AstraZeneca vaccine, despite it still undergoing clinical trials.

“We’re making this ahead of time so should the clinical trial be positive with the outcome that we’re looking for … the vaccine will be available in the short term to distribute to the population,” said CSL’s chief scientific officer Andrew Nash.

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Manufacturing of Oxford University’s COVID-19 vaccine begins

Read more about coronavirus:

‘It’s not a competition’

The Oxford-AstraZeneca COVID-19 vaccine candidate had been among the front-runners in global efforts to develop shots to protect against coronavirus infection.

How are COVID-19 vaccines almost ready so quickly?

A scientist putting medication into a vial in a laboratory.

Previous vaccines have taken years to develop, so why are some COVID-19 candidates ready so quickly, and will they be safe?

Read more

But rival drugmakers Pfizer-BioNTech and Moderna have in the past 10 days edged ahead, releasing data from late-stage COVID-19 vaccine trials that shows more than 90 per cent efficacy.

“We’re not in a rush. We and it’s not a competition with the other developers,” Oxford’s Professor Pollard said, adding that AstraZeneca would release headline efficacy data before it was published in an academic journal.

Oxford University has set a target of 53 infections to start the interim analysis of its late-stage trial results, though “lots of cases” in its trial arms in Britain, South Africa and Brazil mean the exact number of infections reported could differ.

An employee wears a mask, goggles and hairnet at the Brazilian trials for the potential coronavirus vaccine developed by Oxford.
AstraZeneca has reached agreements with governments around the world including in Australia.(Reuters: Amanda Perobelli)

Unlike the Pfizer-BioNTech and Moderna shots, both of which use new technology known as messenger RNA, AstraZeneca’s is a viral vector vaccine made from a weakened version of a common cold virus found in chimpanzees.

The Oxford-AstraZeneca Phase II trial reported in The Lancet involved a total of 560 healthy volunteers, with 160 aged 18-55, 160 aged 56-69, and 240 aged 70 or over.

Volunteers got two doses of the vaccine or a placebo, and no serious side effects related to the vaccine were reported, the researchers said.

AstraZeneca has signed several supply and manufacturing deals with companies and governments around the world.

The Federal Government signed a deal with AstraZeneca in August to lock in supply of the vaccine if trials prove successful.

Prime Minister Scott Morrison has promised to make the vaccine free for all Australians.

Reuters/ABC

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