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Home Science & Environment Medical Research

Recommendations to increase access to whole genome sequencing for children with cancer

December 5, 2024
in Medical Research
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Recommendations to increase access to whole genome sequencing for children with cancer
Credit: BMC Medical Education (2024). DOI: 10.1186/s12909-024-06219-y

Experts have published a series of recommendations for improving equity of access to whole-genome sequencing (WGS) for children with cancer across the U.K.

NHS England is one of the few health services in the world that has a national initiative offering universal genome sequencing to every child with cancer. However, since its rollout in 2021, the use of WGS in clinical practice has not yet seen widespread use and it seems that some childhood cancer units have greater accessibility to this tool than others.

In October 2022, clinicians and scientists from across the U.K. attended a workshop event to discuss some of the reasons behind this. This was organized by the Wellcome Sanger Institute, Wellcome Connecting Science, the CRUK Cambridge Center Pediatric Cancer Program, University of Cambridge Department of Pediatrics and NHS East Genomics.

The results of the workshop, published in BMC Medical Education, highlight some key education and training targets to support uptake and successful implementation of WGS across the U.K.

These include training for health care professionals to better understand the process of requesting WGS in different NHS Trusts, as well as raising awareness that this tool is valuable for clinical management, treatment approaches and research. There is also a need for training around the consent information required, the subsequent potential to identify inherited variants and the best ways to communicate results to children and families.

Key training opportunities identified for clinical scientists included better understanding of how to identify potential opportunities for clinical trials, as well as better understanding of WGS for all health care professionals involved in Genomic Tumor Advisory Boards (GTABs).

Since the workshop, the Cancer Genomic Improvement Program (CGIP) has been established to tackle the end-to-end turnaround times approved for a series of solid tumors and hemato-oncology. Cancer Research UK also recently launched its new genomics policy position statement.

“We designed the workshop to uncover a broad spectrum of implementation barriers, using the COM-B model to pinpoint the key factors essential for driving effective behavior change, in this case, the adoption of whole-genome sequencing. By framing the interactive sessions around targeted questions from the COM-B framework, we identified where education and training could deliver the greatest impact,” says Dr. Michelle Bishop.

“Whole-genome sequencing provides the gold standard, most comprehensive and cutting-edge view of cancer. Despite this, the uptake across the NHS has been varied. Working together with other experts from across the U.K., we have developed recommendations that we hope will help break down the barriers that many face in accessing whole-genome sequencing for their patients.

“This test is a powerful example of how genomics can help provide better, individualized care to children with cancer, and it is important that as many people as possible have access to it,” says Dr. Sam Behjati.

“The East Genomic Laboratory Hub, commissioned to provide whole-genome sequencing testing by NHSE according to the National Genomic Test Directory, recognizes the huge importance of working with our colleagues in pediatric oncology and hemato-oncology to establish clinically useful pathways. The East GLH team of clinical scientists have gained extensive experience in analyzing and reporting pediatric cancer whole genomes and are always keen to support the diffusion of knowledge across the national Genomic Medicine Service.

“This workshop provided an excellent opportunity for knowledge transfer and establishing new training opportunities, ultimately with the aim of supporting equitable access to whole-genome sequencing for all children diagnosed with cancer in the English NHS,” says Dr. Sarah Bowdin.

More information:
Michelle Bishop et al, Identifying barriers and opportunities to facilitate the uptake of whole genome sequencing in paediatric haematology and oncology practice, BMC Medical Education (2024). DOI: 10.1186/s12909-024-06219-y

Provided by
Wellcome Trust Sanger Institute


Citation:
Recommendations to increase access to whole genome sequencing for children with cancer (2024, December 5)
retrieved 5 December 2024
from https://medicalxpress.com/news/2024-12-access-genome-sequencing-children-cancer.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Recommendations to increase access to whole genome sequencing for children with cancer
Credit: BMC Medical Education (2024). DOI: 10.1186/s12909-024-06219-y

Experts have published a series of recommendations for improving equity of access to whole-genome sequencing (WGS) for children with cancer across the U.K.

NHS England is one of the few health services in the world that has a national initiative offering universal genome sequencing to every child with cancer. However, since its rollout in 2021, the use of WGS in clinical practice has not yet seen widespread use and it seems that some childhood cancer units have greater accessibility to this tool than others.

In October 2022, clinicians and scientists from across the U.K. attended a workshop event to discuss some of the reasons behind this. This was organized by the Wellcome Sanger Institute, Wellcome Connecting Science, the CRUK Cambridge Center Pediatric Cancer Program, University of Cambridge Department of Pediatrics and NHS East Genomics.

The results of the workshop, published in BMC Medical Education, highlight some key education and training targets to support uptake and successful implementation of WGS across the U.K.

These include training for health care professionals to better understand the process of requesting WGS in different NHS Trusts, as well as raising awareness that this tool is valuable for clinical management, treatment approaches and research. There is also a need for training around the consent information required, the subsequent potential to identify inherited variants and the best ways to communicate results to children and families.

Key training opportunities identified for clinical scientists included better understanding of how to identify potential opportunities for clinical trials, as well as better understanding of WGS for all health care professionals involved in Genomic Tumor Advisory Boards (GTABs).

Since the workshop, the Cancer Genomic Improvement Program (CGIP) has been established to tackle the end-to-end turnaround times approved for a series of solid tumors and hemato-oncology. Cancer Research UK also recently launched its new genomics policy position statement.

“We designed the workshop to uncover a broad spectrum of implementation barriers, using the COM-B model to pinpoint the key factors essential for driving effective behavior change, in this case, the adoption of whole-genome sequencing. By framing the interactive sessions around targeted questions from the COM-B framework, we identified where education and training could deliver the greatest impact,” says Dr. Michelle Bishop.

“Whole-genome sequencing provides the gold standard, most comprehensive and cutting-edge view of cancer. Despite this, the uptake across the NHS has been varied. Working together with other experts from across the U.K., we have developed recommendations that we hope will help break down the barriers that many face in accessing whole-genome sequencing for their patients.

“This test is a powerful example of how genomics can help provide better, individualized care to children with cancer, and it is important that as many people as possible have access to it,” says Dr. Sam Behjati.

“The East Genomic Laboratory Hub, commissioned to provide whole-genome sequencing testing by NHSE according to the National Genomic Test Directory, recognizes the huge importance of working with our colleagues in pediatric oncology and hemato-oncology to establish clinically useful pathways. The East GLH team of clinical scientists have gained extensive experience in analyzing and reporting pediatric cancer whole genomes and are always keen to support the diffusion of knowledge across the national Genomic Medicine Service.

“This workshop provided an excellent opportunity for knowledge transfer and establishing new training opportunities, ultimately with the aim of supporting equitable access to whole-genome sequencing for all children diagnosed with cancer in the English NHS,” says Dr. Sarah Bowdin.

More information:
Michelle Bishop et al, Identifying barriers and opportunities to facilitate the uptake of whole genome sequencing in paediatric haematology and oncology practice, BMC Medical Education (2024). DOI: 10.1186/s12909-024-06219-y

Provided by
Wellcome Trust Sanger Institute


Citation:
Recommendations to increase access to whole genome sequencing for children with cancer (2024, December 5)
retrieved 5 December 2024
from https://medicalxpress.com/news/2024-12-access-genome-sequencing-children-cancer.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


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