
A new international study published in The American Journal of Clinical Nutrition shows that simply replacing regular bread with a specially formulated oat β-glucan-enriched bread does not significantly improve long-term blood sugar control in individuals at risk of type 2 diabetes.
The 16-week randomized controlled trial, known as the CarbHealth study, involved nearly 200 participants across Germany, Norway, and Sweden. Participants were asked to replace their commonly consumed bread with study bread (a ß-glucan enriched or a wholegrain control bread) and to consume at least 3 slices 6 days a week, mimicking real-life conditions.
The study bread was specifically designed at the Norwegian food research institute (Nofima). It qualifies for an EFSA health claim for foods containing oat beta-glucan that can reduce post-prandial (after-meal) glycemic (blood sugar) responses.
Despite previous evidence from controlled clinical studies suggesting that oat β-glucans can reduce blood glucose and cholesterol levels, this large-scale effectiveness trial found no significant improvements in key metabolic markers such as HbA1c, fasting glucose, insulin, or blood lipids.
“We designed a high-fiber ß-glucan enriched oat bread specifically for this study, aiming to test whether a simple dietary swap could yield measurable health benefits in everyday life,” said lead researcher Dr. Therese Hjorth.
“However, our findings suggest that changing just one food item—even one with proven short-term benefits—is not enough to improve long-term glycemic control.”
The results contrast with earlier efficacy studies conducted under ideal conditions, which formed the basis for health claims approved by the European Food Safety Authority (EFSA). These studies showed that β-glucans can lower postprandial blood glucose and cholesterol levels. The CarbHealth trial, however, highlights the gap between controlled research environments and real-world dietary behavior.
“Our study underscores the importance of a whole-diet approach rather than relying on single-food substitutions,” said co-author Professor Jutta Dierkes. “Even though the oat bread met EFSA’s criteria for β-glucan content, the flexible, real-life consumption patterns likely diluted its potential impact.”
“Functional foods like β-glucan-enriched bread can assist in consuming a healthy diet,” explains Professor Anette Buyken. “Yet broader dietary changes as well as environments facilitating healthy choices are needed to achieve meaningful health outcomes.”
More information:
Therese Hjorth et al, Effectiveness of Regular Oat β-Glucan Enriched Bread Compared to Whole Grain Wheat Bread on Long-Term Glycemic Control in Adults at Risk of Type 2 Diabetes: A Randomized Controlled Trial, The American Journal of Clinical Nutrition (2025). DOI: 10.1016/j.ajcnut.2025.06.018
Citation:
Replacing daily bread with oat β-glucan bread fails to lower key diabetes risk markers (2025, June 30)
retrieved 30 June 2025
from https://medicalxpress.com/news/2025-06-daily-bread-oat-glucan-key.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

A new international study published in The American Journal of Clinical Nutrition shows that simply replacing regular bread with a specially formulated oat β-glucan-enriched bread does not significantly improve long-term blood sugar control in individuals at risk of type 2 diabetes.
The 16-week randomized controlled trial, known as the CarbHealth study, involved nearly 200 participants across Germany, Norway, and Sweden. Participants were asked to replace their commonly consumed bread with study bread (a ß-glucan enriched or a wholegrain control bread) and to consume at least 3 slices 6 days a week, mimicking real-life conditions.
The study bread was specifically designed at the Norwegian food research institute (Nofima). It qualifies for an EFSA health claim for foods containing oat beta-glucan that can reduce post-prandial (after-meal) glycemic (blood sugar) responses.
Despite previous evidence from controlled clinical studies suggesting that oat β-glucans can reduce blood glucose and cholesterol levels, this large-scale effectiveness trial found no significant improvements in key metabolic markers such as HbA1c, fasting glucose, insulin, or blood lipids.
“We designed a high-fiber ß-glucan enriched oat bread specifically for this study, aiming to test whether a simple dietary swap could yield measurable health benefits in everyday life,” said lead researcher Dr. Therese Hjorth.
“However, our findings suggest that changing just one food item—even one with proven short-term benefits—is not enough to improve long-term glycemic control.”
The results contrast with earlier efficacy studies conducted under ideal conditions, which formed the basis for health claims approved by the European Food Safety Authority (EFSA). These studies showed that β-glucans can lower postprandial blood glucose and cholesterol levels. The CarbHealth trial, however, highlights the gap between controlled research environments and real-world dietary behavior.
“Our study underscores the importance of a whole-diet approach rather than relying on single-food substitutions,” said co-author Professor Jutta Dierkes. “Even though the oat bread met EFSA’s criteria for β-glucan content, the flexible, real-life consumption patterns likely diluted its potential impact.”
“Functional foods like β-glucan-enriched bread can assist in consuming a healthy diet,” explains Professor Anette Buyken. “Yet broader dietary changes as well as environments facilitating healthy choices are needed to achieve meaningful health outcomes.”
More information:
Therese Hjorth et al, Effectiveness of Regular Oat β-Glucan Enriched Bread Compared to Whole Grain Wheat Bread on Long-Term Glycemic Control in Adults at Risk of Type 2 Diabetes: A Randomized Controlled Trial, The American Journal of Clinical Nutrition (2025). DOI: 10.1016/j.ajcnut.2025.06.018
Citation:
Replacing daily bread with oat β-glucan bread fails to lower key diabetes risk markers (2025, June 30)
retrieved 30 June 2025
from https://medicalxpress.com/news/2025-06-daily-bread-oat-glucan-key.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.