• Education
    • Higher Education
    • Scholarships & Grants
    • Online Learning
    • School Reforms
    • Research & Innovation
  • Lifestyle
    • Travel
    • Food & Drink
    • Fashion & Beauty
    • Home & Living
    • Relationships & Family
  • Technology & Startups
    • Software & Apps
    • Startup Success Stories
    • Startups & Innovations
    • Tech Regulations
    • Venture Capital
    • Artificial Intelligence
    • Cybersecurity
    • Emerging Technologies
    • Gadgets & Devices
    • Industry Analysis
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy
Today Headline
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
Today Headline
No Result
View All Result
Home Science & Environment Medical Research

Research identifies key enzyme target to fight deadly brain cancers

April 18, 2025
in Medical Research
Reading Time: 3 mins read
A A
0
brain cancer
5
SHARES
11
VIEWS
Share on FacebookShare on Twitter


brain cancer
Credit: Tima Miroshnichenko from Pexels

Researchers have found that targeting an enzyme called PGM3 can help stop the growth of glioblastoma, the most dangerous type of brain tumor. Study findings are published online in the journal Science Advances.

This enzyme plays a vital role in the hexosamine synthesis pathway, which is involved in the processes of protein and lipid glycosylation that allow tumors to rapidly grow. Lipid glycosylation is a process where sugar molecules attach to fats (lipids) in the body.

Researchers with The Ohio State University Comprehensive Cancer Center—Arthur G. James and Richard J. Solove Research Institute believe that targeting PGM3 can reduce tumor growth and eliminate glioblastoma cells.

“This research is important because it has found a new target called PGM3. Blocking the PGM3 enzyme can break the connection between sugar and fat creation in cells, which helps stop tumors from growing. By targeting this enzyme, we can develop more effective treatments for glioblastoma, a brain tumor with very few effective treatment options,” said study lead author Deliang Guo, Ph.D., the founding director of the Center for Cancer Metabolism.

Glioblastoma is a fast-growing brain tumor that develops from glial cells in the brain. An estimated 15,000 people each year are diagnosed with this lethal brain tumor, according to the Glioblastoma Foundation.

The study highlights a promising new approach to fight glioblastoma, giving hope for future advancements in cancer treatment, said Guo, who is also the Urban and Shelly Meyer Professor of Cancer Research with the OSUCCC—James Translational Therapeutics Program and a professor of the Department of Radiation Oncology at The Ohio State University College of Medicine.

“Glioblastoma is the most lethal primary brain tumor, with a median survival of only 12–16 months from diagnosis despite extensive treatments,” said Huali Su, Ph.D., the first author of the paper, and a researcher with the Department of Radiation Oncology and Center for Cancer Metabolism at OSUCCC-James. “New molecular targets for glioblastoma are urgently needed.”

The research team included scientists from France, along with the University of California-Los Angeles, University of California-Irvine and University of Louisville.

More information:
Huali Su et al, Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth, Science Advances (2025). DOI: 10.1126/sciadv.adq0334. www.science.org/doi/10.1126/sciadv.adq0334

Provided by
Ohio State University Medical Center


Citation:
Research identifies key enzyme target to fight deadly brain cancers (2025, April 18)
retrieved 18 April 2025
from https://medicalxpress.com/news/2025-04-key-enzyme-deadly-brain-cancers.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.




brain cancer
Credit: Tima Miroshnichenko from Pexels

Researchers have found that targeting an enzyme called PGM3 can help stop the growth of glioblastoma, the most dangerous type of brain tumor. Study findings are published online in the journal Science Advances.

This enzyme plays a vital role in the hexosamine synthesis pathway, which is involved in the processes of protein and lipid glycosylation that allow tumors to rapidly grow. Lipid glycosylation is a process where sugar molecules attach to fats (lipids) in the body.

Researchers with The Ohio State University Comprehensive Cancer Center—Arthur G. James and Richard J. Solove Research Institute believe that targeting PGM3 can reduce tumor growth and eliminate glioblastoma cells.

“This research is important because it has found a new target called PGM3. Blocking the PGM3 enzyme can break the connection between sugar and fat creation in cells, which helps stop tumors from growing. By targeting this enzyme, we can develop more effective treatments for glioblastoma, a brain tumor with very few effective treatment options,” said study lead author Deliang Guo, Ph.D., the founding director of the Center for Cancer Metabolism.

Glioblastoma is a fast-growing brain tumor that develops from glial cells in the brain. An estimated 15,000 people each year are diagnosed with this lethal brain tumor, according to the Glioblastoma Foundation.

The study highlights a promising new approach to fight glioblastoma, giving hope for future advancements in cancer treatment, said Guo, who is also the Urban and Shelly Meyer Professor of Cancer Research with the OSUCCC—James Translational Therapeutics Program and a professor of the Department of Radiation Oncology at The Ohio State University College of Medicine.

“Glioblastoma is the most lethal primary brain tumor, with a median survival of only 12–16 months from diagnosis despite extensive treatments,” said Huali Su, Ph.D., the first author of the paper, and a researcher with the Department of Radiation Oncology and Center for Cancer Metabolism at OSUCCC-James. “New molecular targets for glioblastoma are urgently needed.”

The research team included scientists from France, along with the University of California-Los Angeles, University of California-Irvine and University of Louisville.

More information:
Huali Su et al, Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth, Science Advances (2025). DOI: 10.1126/sciadv.adq0334. www.science.org/doi/10.1126/sciadv.adq0334

Provided by
Ohio State University Medical Center


Citation:
Research identifies key enzyme target to fight deadly brain cancers (2025, April 18)
retrieved 18 April 2025
from https://medicalxpress.com/news/2025-04-key-enzyme-deadly-brain-cancers.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Tags: Health ResearchHealth Research NewsHealth ScienceMedicine ResearchMedicine Research NewsMedicine Science
Previous Post

Cat wanders onto the White House grounds and joins the press corps

Next Post

Could Mars volcanoes have supported ancient life on the Red Planet? Well, maybe

Related Posts

Scientists create functional 3D-printed human islets for type 1 diabetes treatment

Scientists create functional 3D-printed human islets for type 1 diabetes treatment

June 28, 2025
5
diabetes

People with severe diabetes cured in small stem cell trial

June 28, 2025
7
Next Post
Could Mars volcanoes have supported ancient life on the Red Planet? Well, maybe

Could Mars volcanoes have supported ancient life on the Red Planet? Well, maybe

  • Trending
  • Comments
  • Latest
Family calls for change after B.C. nurse dies by suicide after attacks on the job

Family calls for change after B.C. nurse dies by suicide after attacks on the job

April 2, 2025
Pioneering 3D printing project shares successes

Product reduces TPH levels to non-hazardous status

November 27, 2024

Hospital Mergers Fail to Deliver Better Care or Lower Costs, Study Finds todayheadline

December 31, 2024

Police ID man who died after Corso Italia fight

December 23, 2024
Harris tells supporters 'never give up' and urges peaceful transfer of power

Harris tells supporters ‘never give up’ and urges peaceful transfer of power

0
Des Moines Man Accused Of Shooting Ex-Girlfriend's Mother

Des Moines Man Accused Of Shooting Ex-Girlfriend’s Mother

0

Trump ‘looks forward’ to White House meeting with Biden

0
Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

0
A person with their hands out as if weighing their options.

Better Dividend Stock: Kinder Morgan vs. Enterprise Products Partners todayheadline

June 29, 2025
Trump slams Israel's prosecutors over Netanyahu corruption trial

Trump slams Israel's prosecutors over Netanyahu corruption trial todayheadline

June 29, 2025
ET logo

Man found dead on Melbourne street after possible fall or push from highrise apartment todayheadline

June 29, 2025
Several Seattle beaches closed due to high bacteria, algae levels

Several Seattle beaches closed due to high bacteria, algae levels

June 29, 2025

Recent News

A person with their hands out as if weighing their options.

Better Dividend Stock: Kinder Morgan vs. Enterprise Products Partners todayheadline

June 29, 2025
5
Trump slams Israel's prosecutors over Netanyahu corruption trial

Trump slams Israel's prosecutors over Netanyahu corruption trial todayheadline

June 29, 2025
7
ET logo

Man found dead on Melbourne street after possible fall or push from highrise apartment todayheadline

June 29, 2025
3
Several Seattle beaches closed due to high bacteria, algae levels

Several Seattle beaches closed due to high bacteria, algae levels

June 29, 2025
6

TodayHeadline is a dynamic news website dedicated to delivering up-to-date and comprehensive news coverage from around the globe.

Follow Us

Browse by Category

  • Africa
  • Asia
  • Basketball
  • Business & Finance
  • Climate Change
  • Crime & Justice
  • Cybersecurity
  • Economic Policies
  • Elections
  • Entertainment
  • Entrepreneurship
  • Environmental Policies
  • Europe
  • Football
  • Gadgets & Devices
  • Health
  • Medical Research
  • Mental Health
  • Middle East
  • Motorsport
  • Olympics
  • Politics
  • Public Health
  • Relationships & Family
  • Science & Environment
  • Software & Apps
  • Space Exploration
  • Sports
  • Stock Market
  • Technology & Startups
  • Tennis
  • Travel
  • Uncategorized
  • Us & Canada
  • Wildlife & Conservation
  • World News

Recent News

A person with their hands out as if weighing their options.

Better Dividend Stock: Kinder Morgan vs. Enterprise Products Partners todayheadline

June 29, 2025
Trump slams Israel's prosecutors over Netanyahu corruption trial

Trump slams Israel's prosecutors over Netanyahu corruption trial todayheadline

June 29, 2025
  • Education
  • Lifestyle
  • Technology & Startups
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy

© 2024 Todayheadline.co

Welcome Back!

OR

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Business & Finance
  • Corporate News
  • Economic Policies
  • Entrepreneurship
  • Market Trends
  • Crime & Justice
  • Court Cases
  • Criminal Investigations
  • Cybercrime
  • Legal Reforms
  • Policing
  • Education
  • Higher Education
  • Online Learning
  • Entertainment
  • Awards & Festivals
  • Celebrity News
  • Movies
  • Music
  • Health
  • Fitness & Nutrition
  • Medical Breakthroughs
  • Mental Health
  • Pandemic Updates
  • Lifestyle
  • Fashion & Beauty
  • Food & Drink
  • Home & Living
  • Politics
  • Elections
  • Government Policies
  • International Relations
  • Legislative News
  • Political Parties
  • Africa
  • Asia
  • Europe
  • Middle East
  • Artificial Intelligence
  • Cybersecurity
  • Emerging Technologies
  • Gadgets & Devices
  • Industry Analysis
  • Basketball
  • Football
  • Motorsport
  • Olympics
  • Climate Change
  • Environmental Policies
  • Medical Research
  • Science & Environment
  • Space Exploration
  • Wildlife & Conservation
  • Sports
  • Tennis
  • Technology & Startups
  • Software & Apps
  • Startup Success Stories
  • Startups & Innovations
  • Tech Regulations
  • Venture Capital
  • Uncategorized
  • World News
  • Us & Canada
  • Public Health
  • Relationships & Family
  • Travel
  • Research & Innovation
  • Scholarships & Grants
  • School Reforms
  • Stock Market
  • TV & Streaming
  • Advertise with Us
  • Privacy & Policy
  • About us
  • Contact

© 2024 Todayheadline.co