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Home Science & Environment Medical Research

Research team finds shortcomings in documentation of time-to-event analyses in systematic reviews

December 2, 2024
in Medical Research
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Credit: Pixabay/CC0 Public Domain

Systematic reviews with time-to-event (TTE) analyses provide fundamental insights in many areas of research. TTE data indicate not only whether events (e.g. deaths) have occurred, but also how much time has elapsed between the start of a study and the occurrence of an event. Well-known examples are survival curves, which show how the proportion of patients who survive changes over time, or hazard ratios, which compare the mortality rates of two groups.

TTE analyses are methodologically challenging. Previous research has already highlighted shortcomings in the presentation of TTE results and analyses in clinical trial publications. In this paper, the authors for the first time evaluated the characteristics and methods of meta-analytic TTE analyses in systematic reviews.

To this end, they used a systematic search to identify 50 Cochrane reviews with meta-analyses based on hazard ratios and 50 other systematic reviews from the most important clinical journals.

The research is published in the journal BMC Medical Research Methodology and the Journal of Clinical Epidemiology.

Their evaluation shows that current systematic reviews containing meta-analyses based on hazard ratios provide very different and often inadequate information on TTE characteristics and methods. In a previous publication, the authors had already found this for publications on individual clinical trials. The problem therefore persists in systematic reviews.

The authors conclude that review authors should consistently use the available methodological guidelines for TTE meta-analyses. Moreover, additional reporting standards for TTE analyses in systematic reviews can improve the quality of the reviews and thus the usability of their results.

More information:
Marius Goldkuhle et al, Exploring the characteristics, methods and reporting of systematic reviews with meta-analyses of time-to-event outcomes: a meta-epidemiological study, BMC Medical Research Methodology (2024). DOI: 10.1186/s12874-024-02401-4

Marius Goldkuhle et al, Meta-epidemiological review identified variable reporting and handling of time-to-event analyses in publications of trials included in meta-analyses of systematic reviews, Journal of Clinical Epidemiology (2023). DOI: 10.1016/j.jclinepi.2023.05.023

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Institute for Quality and Efficiency in Health Care


Citation:
Research team finds shortcomings in documentation of time-to-event analyses in systematic reviews (2024, December 2)
retrieved 2 December 2024
from https://medicalxpress.com/news/2024-12-team-shortcomings-documentation-event-analyses.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



research paper
Credit: Pixabay/CC0 Public Domain

Systematic reviews with time-to-event (TTE) analyses provide fundamental insights in many areas of research. TTE data indicate not only whether events (e.g. deaths) have occurred, but also how much time has elapsed between the start of a study and the occurrence of an event. Well-known examples are survival curves, which show how the proportion of patients who survive changes over time, or hazard ratios, which compare the mortality rates of two groups.

TTE analyses are methodologically challenging. Previous research has already highlighted shortcomings in the presentation of TTE results and analyses in clinical trial publications. In this paper, the authors for the first time evaluated the characteristics and methods of meta-analytic TTE analyses in systematic reviews.

To this end, they used a systematic search to identify 50 Cochrane reviews with meta-analyses based on hazard ratios and 50 other systematic reviews from the most important clinical journals.

The research is published in the journal BMC Medical Research Methodology and the Journal of Clinical Epidemiology.

Their evaluation shows that current systematic reviews containing meta-analyses based on hazard ratios provide very different and often inadequate information on TTE characteristics and methods. In a previous publication, the authors had already found this for publications on individual clinical trials. The problem therefore persists in systematic reviews.

The authors conclude that review authors should consistently use the available methodological guidelines for TTE meta-analyses. Moreover, additional reporting standards for TTE analyses in systematic reviews can improve the quality of the reviews and thus the usability of their results.

More information:
Marius Goldkuhle et al, Exploring the characteristics, methods and reporting of systematic reviews with meta-analyses of time-to-event outcomes: a meta-epidemiological study, BMC Medical Research Methodology (2024). DOI: 10.1186/s12874-024-02401-4

Marius Goldkuhle et al, Meta-epidemiological review identified variable reporting and handling of time-to-event analyses in publications of trials included in meta-analyses of systematic reviews, Journal of Clinical Epidemiology (2023). DOI: 10.1016/j.jclinepi.2023.05.023

Provided by
Institute for Quality and Efficiency in Health Care


Citation:
Research team finds shortcomings in documentation of time-to-event analyses in systematic reviews (2024, December 2)
retrieved 2 December 2024
from https://medicalxpress.com/news/2024-12-team-shortcomings-documentation-event-analyses.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


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