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The side effects I had after my second COVID-19 vaccine shot

January 8, 2021
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The side effects I had after my second COVID-19 vaccine shot
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  • Dr. Joy Henningsen is a diagnostic radiologist at the Birmingham Veterans Affairs Medical Center and a clinical assistant professor at the University of Alabama at Birmingham. 
  • She received the first dose of the Pfizer/BioNTech COVID-19 vaccine on December 17 and the second dose on January 7 at the Birmingham VA Medical Center. 
  • Although she experienced no side effects following the first shot, about six hours after the second dose Henningsen says she began to feel muscle aches and injection site soreness.
  • She woke up during the night at the 12-hour mark with a fever and chills that subsided by morning, but she felt lingering effects the next day.
  • Henningsen says although these temporary side effects are uncomfortable, they won’t happen to everyone and shouldn’t be a deterrent to receiving the vaccine.
  • Visit Business Insider’s homepage for more stories.

I was extremely fortunate to receive the initial dose of the Pfizer COVID-19 vaccine on December 17, the first week it was offered in the United States outside of a clinical trial. My hospital received doses in the first national shipment and every healthcare worker at my hospital who expressed interest via survey received the vaccine, including me. 

I barely felt the first shot, aside from very subtle arm soreness a day or so later. 

I also signed up to log my symptoms on the CDC’s V-Safe online symptom tracker tool. My reporting was wholly uneventful; thankfully, as expected, I had no symptoms that impacted my life or activities in any way. 

I wondered if I’d be as lucky after the second dose, when more people have reported uncomfortable side effects.

Read more: Investors think Amazon and Alphabet could set the pace for healthcare deals in 2021. Here’s what they are watching.

Before I knew how my body would react to the second dose, I prepared myself for the possibility of feeling lousy for a day or two afterward.

Joy Henningsen

Henningsen prepared washcloths, a thermometer, and over the counter pain medications for after the shot.

Joy Henningsen


If it were an option, I would have scheduled the day off work after the second vaccination to be safe. For me that wasn’t possible, so I scheduled a grocery delivery before my shot and purchased the same items I’d buy if I had a cold or the flu (water, soup, crackers, etc.) I also made sure my pets were stocked up with plenty of food and water. 

In addition to comfort food and hydrating liquids, I cobbled together a “vaccine valise” of other supplies to have on hand.

This included an under-tongue thermometer to monitor my temperature and over-the-counter fever reducers. For the whiplash back and forth between fever and chills that some people have reported, I set out washcloths to be used as cold compresses. I also put a weighted blanket and a down comforter nearby my bed.

I received my vaccine in the afternoon on January 7.

The second dose of the COVID-19 vaccine that Henningsen received.

The second dose of the COVID-19 vaccine that Henningsen received.

Joy Henningsen


I felt fine until the six-hour mark, when I began to feel a sense of malaise (the medical word for that vague feeling when you know something isn’t quite right at the beginning of feeling sick). 

Mild muscle aches soon followed, as well as injection site soreness that felt similar to how a tetanus shot feels, that is, a little worse than a flu shot. I fell asleep but not restfully; I woke up at the 12-hour mark with a 102-degree fever and chills that subsided by morning. Still, when I woke up the muscle aches persisted, and I had a dull headache similar to what I’d feel if I skipped my daily coffee. 24 hours later, the headache, exhaustion, chills, and “blah” feeling is still here.

Still, all of my symptoms are mild and a very small price to pay for protection against COVID-19. I believe temporary discomfort should not be a deterrent to receiving the vaccine, and I know these symptoms are a sign of a robust immune system and that my body is priming itself to fight COVID-19 — exactly what it is supposed to do.

Read more: A group backed by huge employers like Walmart, Lowe’s, and Microsoft is working on a new initiative to lower healthcare costs

It’s important we’re prepared for the possibility of these side effects. 

Joy Henningsen

Henningsen with her vaccine form.

Joy Henningsen


The Pfizer vaccine was vetted by the US Food and Drug Administration which determined that it was safe to be given to people over 16. Millions of Americans need to be prepared for the authorized COVID-19 vaccines’ potential side effects such as fatigue, headache, muscle pains, fever, and chills that are more common with the second dose. For the majority of recipients, these potential effects may be an uncomfortable, but not threatening, part of this vaccine. 

According to Dr. Anthony Fauci’s latest projections, we need approximately 90% of Americans to be immunized to achieve herd immunity in order to resume normal life. I believe it’s our civic responsibility to be vaccinated according to the recommended dose regimen to end the pandemic. We all benefit.  

It’s smart to prepare yourself for the possibility that dose two of the authorized COVID-19 vaccines may be slightly more challenging. Still, having seen the destruction SARS-CoV-2 can wreak upon the body, I can tell you I’d rather have a night of feeling lousy on the couch watching Netflix any day over serious COVID-19. 

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