Bayern dominated at the Tottenham Hotspur Stadium, with former Arsenal ace Serge Gnabry running riot.
The winger netted four, with Robert Lewandowski adding a brace.
Joshua Kimmich also scored to embarrass Tottenham in their own back yard.
And Tottenham fans took to social media to demand the Argentine leaves Spurs after their Champions League humiliation.
One fan wrote on Twitter: “Poch & Levy have to go. This is the end of both of them.
Another added: “I love Poch but he’s done.
“Give the option to him walk away rather sack him out of respect. Before this gets toxic.”
“This is the worst spurs performance I’ve seen all my life. We were humiliated in our own backyard,” fumed another fan.
“I think it’s time for a change in management #pochout.”
Another said: “Can’t even be mad. We’re a laughing stock and always have been.
“Rose & Aurier are the worst fullback combination in the whole of English football. Tactics are absolutely all over the place.
“Poch has done absolute bits for the club, but maybe he needs to go elsewhere.”
Tottenham have had a hit and miss start to the season under Pochettino this time out.
Spurs were knocked out of the Carabao Cup last week by Colchester, while the north London club are already ten points behind Premier League leaders Liverpool after just seven games.
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