• About Us
  • Contact Us
  • Cookie policy (EU)
  • Home
  • Privacy Policy
  • Video
  • Write for us
Today Headline
  • HOME
  • NEWS
    • POLITICS
    • News for today
    • Borisov news
  • FINANCE
    • Business
    • Insurance
  • Video
  • TECHNOLOGY
  • ENTERPRISE
  • LIFESTYLE
    • TRAVEL
    • HEALTH
    • ENTERTAINMENT
  • AUTOMOTIVE
  • SPORTS
  • Travel and Tourism
  • HOME
  • NEWS
    • POLITICS
    • News for today
    • Borisov news
  • FINANCE
    • Business
    • Insurance
  • Video
  • TECHNOLOGY
  • ENTERPRISE
  • LIFESTYLE
    • TRAVEL
    • HEALTH
    • ENTERTAINMENT
  • AUTOMOTIVE
  • SPORTS
  • Travel and Tourism
No Result
View All Result
TodayHeadline
No Result
View All Result

Transparent ultrasound chip improves cell stimulation and imaging

February 26, 2022
in Technology
0
Transparent ultrasound chip improves cell stimulation and imaging
0
SHARES
1
VIEWS
Share on FacebookShare on Twitter


“In the conventional ultrasound stimulation experiments, a cell culture dish is placed in a water bath, and a bulky ultrasound transducer directs the ultrasound waves to the cells through the water medium,” said Sri-Rajasekhar “Raj” Kothapalli, principal investigator and assistant professor of biomedical engineering at Penn State. “This was a complex setup that didn’t provide reproducible results: The results that one group saw another did not, even while using the same parameters, because there are several things that could affect the cells’ survival and stimulation while they are in water, as well as how we visualize them.”

Kothapalli and his collaborators miniaturized the ultrasound stimulation setup by creating a transparent transducer platform made of a piezoelectric lithium niobate material. Piezoelectric materials generate mechanical energy when electric voltage is applied. The chip’s biocompatible surface allows the cells to be cultured directly on the transducer and used for repeated stimulation experiments over several weeks.

When connected to a power supply, the transducer emits ultrasound waves, which pulse the cells and trigger ion influx and outflux.

To test the setup, Kothapalli and his team cultured bladder cancer cells on the chip. They then inserted fluorescent calcium indicators into the cells to allow researchers to clearly see dynamic changes in cell calcium signaling under the microscope during stimulation.

“Since the cells are directly sitting on the transparent transducer surface, we can confirm that all the cells are equally stimulated at the same time using a single ultrasound stimulus, unlike conventional approaches,” Kothapalli, a co-hire with the Penn State Cancer Institutesaid. “And unlike earlier processes, we can get high resolution images of many cells at once in a single field of view, because we are able to see the cells from a close distance.”

Through the bladder cancer cell study, researchers established proof-of-concept for the new transducer setup. But they can extend these findings to use the transducer setup in potential future applications, according to Kothapalli, such as stem cell differentiation, mechanosensitive neuromodulation, drug delivery and the opening of the blood-brain barrier.

Tags: Cellchipimagingimprovesstimulationtransparentultrasound
Previous Post

COVID vaccine effectiveness declines after 6 months without boosters

Next Post

India’s rural energy pioneers — Global Issues

Related Posts

Using tactile sensors and machine learning to improve how robots manipulate fabrics
Technology

Using tactile sensors and machine learning to improve how robots manipulate fabrics

1) We initially approach the...

Read more
Is propane a solution for more sustainable air conditioning?
Technology

Is propane a solution for more sustainable air conditioning?

Credit: Pixabay/CC0 Public Domain Current...

Read more
Solid-state memory in neuromorphic circuits
Technology

Solid-state memory in neuromorphic circuits

Schematic connection of two biological...

Read more
Open-source software gives a leg up to robot research
Technology

Open-source software gives a leg up to robot research

Quad-SDK is an open-source, full-stack...

Read more
AI-designed camera only records objects of interest while being blind to others
Technology

AI-designed camera only records objects of interest while being blind to others

Object class-specific imaging using a...

Read more
Load More
Next Post
India’s rural energy pioneers — Global Issues

India’s rural energy pioneers — Global Issues

  • Trending
  • Comments
  • Latest
Collapsed Doggy sex position promises clitoral stimulation for extra pleasure

Collapsed Doggy sex position promises clitoral stimulation for extra pleasure

Six times actors really romped in sex scenes that make 365 DNI look tame

Six times actors really romped in sex scenes that make 365 DNI look tame

My partner has to pay more car insurance – because he was born outside the UK | Car insurance

Trisha Paytas Destroyed The Internet By Posting Her Toilet Paper Asshole

Trisha Paytas Destroyed The Internet By Posting Her Toilet Paper Asshole

Why did Demi Lovato and Wilmer Valderrama break up?

Why did Demi Lovato and Wilmer Valderrama break up?

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Reuters reveals Rotavirus childhood vaccine shortage hits four African countries

Reuters reveals Rotavirus childhood vaccine shortage hits four African countries

Chemical-free weed is hot in L.A. Here’s why.

Chemical-free weed is hot in L.A. Here’s why.

About Us

Todayheadline the independent news and topics discovery
A home-grown and independent news and topic aggregation . displays breaking news linking to news websites all around the world.

Follow Us

Latest News

Why did Demi Lovato and Wilmer Valderrama break up?

Why did Demi Lovato and Wilmer Valderrama break up?

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Why did Demi Lovato and Wilmer Valderrama break up?

Why did Demi Lovato and Wilmer Valderrama break up?

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Using tactile sensors and machine learning to improve how robots manipulate fabrics

Reuters reveals Rotavirus childhood vaccine shortage hits four African countries

Reuters reveals Rotavirus childhood vaccine shortage hits four African countries

  • Real Estate
  • Education
  • Parenting
  • Cooking
  • NFL Games On TV Today
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2021 All rights are reserved Todayheadline

No Result
View All Result
  • Real Estate
  • Education
  • Parenting
  • Cooking
  • NFL Games On TV Today
  • Travel and Tourism
  • Home & Garden
  • Pets
  • Privacy & Policy
  • Contact
  • About

© 2021 All rights are reserved Todayheadline

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist