Britain has become the first country to approve a COVID vaccine that targets both the original and Omicron variant of the coronavirus.
The British medicines regulator (MHRA) approved the so-called bivalent vaccine made by US drug company Moderna as a booster for adults.
The agency’s decision was based on clinical trial data that showed the booster triggered ‘‘a strong immune response’’ against Omicron (BA.1) and the original 2020 virus, it said on Monday.
The MHRA also cited an exploratory analysis in which the shot was found to generate a good immune response against the dominant Omicron offshoots BA.4 and BA.5.
We are pleased to announce that we have approved the UK’s first bivalent COVID-19 booster vaccine, made by @moderna_tx.
For more information see: https://t.co/MLXObQqyUt pic.twitter.com/VNelnGBfVD
— MHRAgovuk (@MHRAgovuk) August 15, 2022
No serious safety concerns were identified with the formulation, the agency said.
Now approval has been secured, Britain’s Joint Committee on Vaccination and Immunisation will advise on how the vaccine should be deployed.
Although existing COVID vaccines continue to provide good protection against hospitalisation and death, vaccine effectiveness has taken a hit as the virus has evolved.
“The first generation of COVID-19 vaccines being used in the UK continue to provide important protection against the disease and save lives,” MHRA chief executive June Raine said in a statement.
“What this bivalent vaccine gives us is a sharpened tool in our armoury to help protect us against this disease as the virus continues to evolve.”
European Medicines Agency officials expect COVID variant-adapted vaccines to be approved in the European Union by September, and have signalled the regulator is open to using shots targeting the older BA.1 variant this autumn, given those specifically targeting newer subvariants are further behind in clinical development.
In contrast, the US Food and Drug Administration has said it will seek the specific inclusion of the newer BA.4 and BA.5 offshoots of Omicron in any new shots used domestically.
Apart from Moderna, partners Pfizer and BioNTech have also been testing versions of their mRNA vaccine modified to combat Omicron variants.
Meanwhile, Sanofi and partner GSK are working on a protein-based vaccine that targets the Beta subvariant, which dominated for some time last year.