• Education
    • Higher Education
    • Scholarships & Grants
    • Online Learning
    • School Reforms
    • Research & Innovation
  • Lifestyle
    • Travel
    • Food & Drink
    • Fashion & Beauty
    • Home & Living
    • Relationships & Family
  • Technology & Startups
    • Software & Apps
    • Startup Success Stories
    • Startups & Innovations
    • Tech Regulations
    • Venture Capital
    • Artificial Intelligence
    • Cybersecurity
    • Emerging Technologies
    • Gadgets & Devices
    • Industry Analysis
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy
Today Headline
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
Today Headline
No Result
View All Result
Home Science & Environment Medical Research

Antibody-mediated protection mechanism expands tuberculosis treatment options

May 30, 2025
in Medical Research
Reading Time: 3 mins read
A A
0
Ragon Institute study uncovers how certain antibodies help fight tuberculosis
2
SHARES
4
VIEWS
Share on FacebookShare on Twitter


Ragon Institute study uncovers how certain antibodies help fight tuberculosis
scRNA-seq of αLAΜ-mIgG2a-treated and –mIgG2a N297A-treated lung cells reveals distinct AM and PMN states. Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.05.004

Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body’s ability to fight Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis (TB). Despite decades of research, TB remains one of the deadliest infectious diseases worldwide, with about 10 million new cases and 1.6 million deaths annually. Currently, there is no highly effective vaccine, highlighting the urgent need for new insights and treatments.

In a study published today in Immunity, Ragon faculty member Galit Alter, Ph.D. and previous post-doctoral trainee Patricia Grace, Ph.D., now at University of Pittsburgh, partnered with Bryan Bryson, Ph.D., associate member Sarah Fortune, Ph.D. and a team of collaborators, to collect the largest library of monoclonal antibodies to Mycobacterium tuberculosis (Mtb) the bacteria that causes tuberculosis.

The team identified specific antibody features that significantly limit the growth of Mtb. This research reveals critical new insights into how antibodies interact with immune cells in the lungs to restrict Mtb infection, laying the groundwork for potential antibody-based therapies or vaccines against tuberculosis, both of which are urgently needed.

The team investigated monoclonal antibodies (mAbs), highly specialized antibodies engineered to target specific components of Mtb. They screened a broad library of these antibodies, targeting many different components of the bacteria, to determine which could effectively reduce bacterial growth in infected mice.

They found that particular antibodies targeting different parts of the bacteria—both surface proteins and internal antigens—could effectively restrict Mtb growth, challenging previous assumptions that only antibodies recognizing surface structures could help fight TB.

To better understand the mechanisms behind this antibody-mediated protection, researchers closely examined one particularly effective antibody targeting a molecule called lipoarabinomannan (LAM), found on the bacterial cell surface.

By engineering the antibody constant domain (Fc) to control the killing activities of the antibody, the researchers discovered that maximal bacterial control was achieved when antibodies redirected innate immune cell recruitment and activation. Particularly, antibodies able to redirect the bacteria to neutrophils provided the greatest level of protection.

This discovery highlights a previously unrecognized way antibodies can work against TB not merely by neutralizing pathogens directly, but by reshaping immune cell functions within infected tissues.

Given the rise in antibiotic resistant bacteria, understanding these immune mechanisms opens new avenues for novel therapeutic and vaccine designs that are urgently needed to combat TB. Moreover, this study unlocks future approaches to rapidly discover and design monoclonal therapeutics to a broader array of antibiotic-resistant bacteria in the future.

More information:
Patricia S. Grace et al. Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction., Immunity (2025). DOI: 10.1016/j.immuni.2025.05.004. www.cell.com/immunity/fulltext … 1074-7613(25)00225-0

Provided by
Ragon Institute of MGH, MIT and Harvard

Citation:
Antibody-mediated protection mechanism expands tuberculosis treatment options (2025, May 30)
retrieved 30 May 2025
from https://medicalxpress.com/news/2025-05-antibody-mechanism-tuberculosis-treatment-options.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Ragon Institute study uncovers how certain antibodies help fight tuberculosis
scRNA-seq of αLAΜ-mIgG2a-treated and –mIgG2a N297A-treated lung cells reveals distinct AM and PMN states. Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.05.004

Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body’s ability to fight Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis (TB). Despite decades of research, TB remains one of the deadliest infectious diseases worldwide, with about 10 million new cases and 1.6 million deaths annually. Currently, there is no highly effective vaccine, highlighting the urgent need for new insights and treatments.

In a study published today in Immunity, Ragon faculty member Galit Alter, Ph.D. and previous post-doctoral trainee Patricia Grace, Ph.D., now at University of Pittsburgh, partnered with Bryan Bryson, Ph.D., associate member Sarah Fortune, Ph.D. and a team of collaborators, to collect the largest library of monoclonal antibodies to Mycobacterium tuberculosis (Mtb) the bacteria that causes tuberculosis.

The team identified specific antibody features that significantly limit the growth of Mtb. This research reveals critical new insights into how antibodies interact with immune cells in the lungs to restrict Mtb infection, laying the groundwork for potential antibody-based therapies or vaccines against tuberculosis, both of which are urgently needed.

The team investigated monoclonal antibodies (mAbs), highly specialized antibodies engineered to target specific components of Mtb. They screened a broad library of these antibodies, targeting many different components of the bacteria, to determine which could effectively reduce bacterial growth in infected mice.

They found that particular antibodies targeting different parts of the bacteria—both surface proteins and internal antigens—could effectively restrict Mtb growth, challenging previous assumptions that only antibodies recognizing surface structures could help fight TB.

To better understand the mechanisms behind this antibody-mediated protection, researchers closely examined one particularly effective antibody targeting a molecule called lipoarabinomannan (LAM), found on the bacterial cell surface.

By engineering the antibody constant domain (Fc) to control the killing activities of the antibody, the researchers discovered that maximal bacterial control was achieved when antibodies redirected innate immune cell recruitment and activation. Particularly, antibodies able to redirect the bacteria to neutrophils provided the greatest level of protection.

This discovery highlights a previously unrecognized way antibodies can work against TB not merely by neutralizing pathogens directly, but by reshaping immune cell functions within infected tissues.

Given the rise in antibiotic resistant bacteria, understanding these immune mechanisms opens new avenues for novel therapeutic and vaccine designs that are urgently needed to combat TB. Moreover, this study unlocks future approaches to rapidly discover and design monoclonal therapeutics to a broader array of antibiotic-resistant bacteria in the future.

More information:
Patricia S. Grace et al. Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction., Immunity (2025). DOI: 10.1016/j.immuni.2025.05.004. www.cell.com/immunity/fulltext … 1074-7613(25)00225-0

Provided by
Ragon Institute of MGH, MIT and Harvard

Citation:
Antibody-mediated protection mechanism expands tuberculosis treatment options (2025, May 30)
retrieved 30 May 2025
from https://medicalxpress.com/news/2025-05-antibody-mechanism-tuberculosis-treatment-options.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


Tags: Health ResearchHealth Research NewsHealth ScienceMedicine ResearchMedicine Research NewsMedicine Science
Previous Post

Missing 10-year-old girl’s remains identified after Panga boat capsized off California coast

Next Post

A fireball over desert mountains photo of the day for May 30, 2025

Related Posts

Autism and ADHD have distinct brain connectivity signatures, study finds

Autism and ADHD have distinct brain connectivity signatures, study finds

May 31, 2025
8

Journalists Draw Link Between Internet Dead Zones, Threatened Medicaid Cuts, and Health

May 31, 2025
8
Next Post
a red-tinted streak from a meteor plunges through a greenish-blue sky above the dome of an astronomical observatory

A fireball over desert mountains photo of the day for May 30, 2025

  • Trending
  • Comments
  • Latest
Family calls for change after B.C. nurse dies by suicide after attacks on the job

Family calls for change after B.C. nurse dies by suicide after attacks on the job

April 2, 2025
Pioneering 3D printing project shares successes

Product reduces TPH levels to non-hazardous status

November 27, 2024

Hospital Mergers Fail to Deliver Better Care or Lower Costs, Study Finds todayheadline

December 31, 2024

Police ID man who died after Corso Italia fight

December 23, 2024
Harris tells supporters 'never give up' and urges peaceful transfer of power

Harris tells supporters ‘never give up’ and urges peaceful transfer of power

0
Des Moines Man Accused Of Shooting Ex-Girlfriend's Mother

Des Moines Man Accused Of Shooting Ex-Girlfriend’s Mother

0

Trump ‘looks forward’ to White House meeting with Biden

0
Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

0
'Gaza has won, and Gaza will win': Arab MK's speech at anti-war rally draws outrage

‘Gaza has won, and Gaza will win’: Arab MK’s speech at anti-war rally draws outrage

May 31, 2025
Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built'

Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built' todayheadline

May 31, 2025
BoE's Breeden sees loosening labour market and disinflation, Sunday Times reports

BoE's Breeden sees loosening labour market and disinflation, Sunday Times reports todayheadline

May 31, 2025
ET logo

A Yankees fan claims stadium debris fell from the sky during World Series rematch, Dodgers scramble to investigate todayheadline

May 31, 2025

Recent News

'Gaza has won, and Gaza will win': Arab MK's speech at anti-war rally draws outrage

‘Gaza has won, and Gaza will win’: Arab MK’s speech at anti-war rally draws outrage

May 31, 2025
3
Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built'

Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built' todayheadline

May 31, 2025
7
BoE's Breeden sees loosening labour market and disinflation, Sunday Times reports

BoE's Breeden sees loosening labour market and disinflation, Sunday Times reports todayheadline

May 31, 2025
4
ET logo

A Yankees fan claims stadium debris fell from the sky during World Series rematch, Dodgers scramble to investigate todayheadline

May 31, 2025
7

TodayHeadline is a dynamic news website dedicated to delivering up-to-date and comprehensive news coverage from around the globe.

Follow Us

Browse by Category

  • Africa
  • Asia
  • Basketball
  • Business & Finance
  • Climate Change
  • Crime & Justice
  • Cybersecurity
  • Economic Policies
  • Elections
  • Entertainment
  • Entrepreneurship
  • Environmental Policies
  • Europe
  • Football
  • Gadgets & Devices
  • Health
  • Medical Research
  • Mental Health
  • Middle East
  • Motorsport
  • Olympics
  • Politics
  • Public Health
  • Relationships & Family
  • Science & Environment
  • Software & Apps
  • Space Exploration
  • Sports
  • Stock Market
  • Technology & Startups
  • Tennis
  • Travel
  • Uncategorized
  • Us & Canada
  • Wildlife & Conservation
  • World News

Recent News

'Gaza has won, and Gaza will win': Arab MK's speech at anti-war rally draws outrage

‘Gaza has won, and Gaza will win’: Arab MK’s speech at anti-war rally draws outrage

May 31, 2025
Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built'

Walmart is selling an 'amazing' $649 electric scooter for $327, and shoppers say it's 'very well built' todayheadline

May 31, 2025
  • Education
  • Lifestyle
  • Technology & Startups
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy

© 2024 Todayheadline.co

Welcome Back!

OR

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Business & Finance
  • Corporate News
  • Economic Policies
  • Entrepreneurship
  • Market Trends
  • Crime & Justice
  • Court Cases
  • Criminal Investigations
  • Cybercrime
  • Legal Reforms
  • Policing
  • Education
  • Higher Education
  • Online Learning
  • Entertainment
  • Awards & Festivals
  • Celebrity News
  • Movies
  • Music
  • Health
  • Fitness & Nutrition
  • Medical Breakthroughs
  • Mental Health
  • Pandemic Updates
  • Lifestyle
  • Fashion & Beauty
  • Food & Drink
  • Home & Living
  • Politics
  • Elections
  • Government Policies
  • International Relations
  • Legislative News
  • Political Parties
  • Africa
  • Asia
  • Europe
  • Middle East
  • Artificial Intelligence
  • Cybersecurity
  • Emerging Technologies
  • Gadgets & Devices
  • Industry Analysis
  • Basketball
  • Football
  • Motorsport
  • Olympics
  • Climate Change
  • Environmental Policies
  • Medical Research
  • Science & Environment
  • Space Exploration
  • Wildlife & Conservation
  • Sports
  • Tennis
  • Technology & Startups
  • Software & Apps
  • Startup Success Stories
  • Startups & Innovations
  • Tech Regulations
  • Venture Capital
  • Uncategorized
  • World News
  • Us & Canada
  • Public Health
  • Relationships & Family
  • Travel
  • Research & Innovation
  • Scholarships & Grants
  • School Reforms
  • Stock Market
  • TV & Streaming
  • Advertise with Us
  • Privacy & Policy
  • About us
  • Contact

© 2024 Todayheadline.co