• Education
    • Higher Education
    • Scholarships & Grants
    • Online Learning
    • School Reforms
    • Research & Innovation
  • Lifestyle
    • Travel
    • Food & Drink
    • Fashion & Beauty
    • Home & Living
    • Relationships & Family
  • Technology & Startups
    • Software & Apps
    • Startup Success Stories
    • Startups & Innovations
    • Tech Regulations
    • Venture Capital
    • Artificial Intelligence
    • Cybersecurity
    • Emerging Technologies
    • Gadgets & Devices
    • Industry Analysis
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy
Today Headline
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
  • Home
  • World News
    • Us & Canada
    • Europe
    • Asia
    • Africa
    • Middle East
  • Politics
    • Elections
    • Political Parties
    • Government Policies
    • International Relations
    • Legislative News
  • Business & Finance
    • Market Trends
    • Stock Market
    • Entrepreneurship
    • Corporate News
    • Economic Policies
  • Science & Environment
    • Space Exploration
    • Climate Change
    • Wildlife & Conservation
    • Environmental Policies
    • Medical Research
  • Health
    • Public Health
    • Mental Health
    • Medical Breakthroughs
    • Fitness & Nutrition
    • Pandemic Updates
  • Sports
    • Football
    • Basketball
    • Tennis
    • Olympics
    • Motorsport
  • Entertainment
    • Movies
    • Music
    • TV & Streaming
    • Celebrity News
    • Awards & Festivals
  • Crime & Justice
    • Court Cases
    • Cybercrime
    • Policing
    • Criminal Investigations
    • Legal Reforms
No Result
View All Result
Today Headline
No Result
View All Result
Home Science & Environment Medical Research

Breakthrough provides potential for precise melanoma treatment

April 7, 2025
in Medical Research
Reading Time: 2 mins read
A A
0
Breakthrough provides potential for precise melanoma treatment
3
SHARES
7
VIEWS
Share on FacebookShare on Twitter


Breakthrough provides potential for precise melanoma treatment
Targeted methylation sequencing in order to validate the 850K methylation data. Credit: Cancer Letters (2025). DOI: 10.1016/j.canlet.2025.217638

A major step forward has been made in predicting how well melanoma patients would respond to treatment, thanks to world-leading University of Otago—Ōtākou Whakaihu Waka research.

More than 7,000 melanomas are diagnosed each year in Aotearoa New Zealand, and nearly 300 people annually lose their lives to the disease.

Immunotherapy treatment, particularly Keytruda (anti-PD1 therapy), is the main frontline medicine used to treat skin cancer. However, only about 30%–40% of melanoma patients respond to Keytruda effectively, underscoring the need for biomarkers to predict treatment success.

New research published in Cancer Letters, led by Professor Mike Eccles from the Department of Pathology, has identified key epigenetic differences—specifically in DNA methylation and gene expression—that correlate significantly with melanoma patient responses to Keytruda treatment.

The significant findings have the potential to enable doctors to determine which patients can be successfully treated with the drug.

“This breakthrough offers the potential for more precise and effective melanoma treatment, which would enable clinicians to tailor therapeutic strategies based on each patient’s individual genomic profiles,” Professor Eccles says.

“Biomarkers are urgently needed to help treat melanoma patients—the potential to predict personalized treatment strategies is a major step forward in improving patient outcomes, both across Aotearoa and globally.”

More information:
Sultana Mehbuba Hossain et al, Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapy, Cancer Letters (2025). DOI: 10.1016/j.canlet.2025.217638

Provided by
University of Otago


Citation:
Breakthrough provides potential for precise melanoma treatment (2025, April 7)
retrieved 7 April 2025
from https://medicalxpress.com/news/2025-04-breakthrough-potential-precise-melanoma-treatment.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.




Breakthrough provides potential for precise melanoma treatment
Targeted methylation sequencing in order to validate the 850K methylation data. Credit: Cancer Letters (2025). DOI: 10.1016/j.canlet.2025.217638

A major step forward has been made in predicting how well melanoma patients would respond to treatment, thanks to world-leading University of Otago—Ōtākou Whakaihu Waka research.

More than 7,000 melanomas are diagnosed each year in Aotearoa New Zealand, and nearly 300 people annually lose their lives to the disease.

Immunotherapy treatment, particularly Keytruda (anti-PD1 therapy), is the main frontline medicine used to treat skin cancer. However, only about 30%–40% of melanoma patients respond to Keytruda effectively, underscoring the need for biomarkers to predict treatment success.

New research published in Cancer Letters, led by Professor Mike Eccles from the Department of Pathology, has identified key epigenetic differences—specifically in DNA methylation and gene expression—that correlate significantly with melanoma patient responses to Keytruda treatment.

The significant findings have the potential to enable doctors to determine which patients can be successfully treated with the drug.

“This breakthrough offers the potential for more precise and effective melanoma treatment, which would enable clinicians to tailor therapeutic strategies based on each patient’s individual genomic profiles,” Professor Eccles says.

“Biomarkers are urgently needed to help treat melanoma patients—the potential to predict personalized treatment strategies is a major step forward in improving patient outcomes, both across Aotearoa and globally.”

More information:
Sultana Mehbuba Hossain et al, Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapy, Cancer Letters (2025). DOI: 10.1016/j.canlet.2025.217638

Provided by
University of Otago


Citation:
Breakthrough provides potential for precise melanoma treatment (2025, April 7)
retrieved 7 April 2025
from https://medicalxpress.com/news/2025-04-breakthrough-potential-precise-melanoma-treatment.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Tags: Health ResearchHealth Research NewsHealth ScienceMedicine ResearchMedicine Research NewsMedicine Science
Previous Post

Trump: Tariffs sparking investment in US

Next Post

AI-based project provides accurate, real-time, hyper-local air quality data, says group behind it

Related Posts

premature baby

Despite overall progress, low birthweight rates still high in certain Indian states

June 16, 2025
5
Mellow Fellow

Unlocking the Secrets of Sleep, Energy and Relaxation: The Role of Cannabinoids

June 16, 2025
6
Next Post
fractals

AI-based project provides accurate, real-time, hyper-local air quality data, says group behind it

  • Trending
  • Comments
  • Latest
Family calls for change after B.C. nurse dies by suicide after attacks on the job

Family calls for change after B.C. nurse dies by suicide after attacks on the job

April 2, 2025
Pioneering 3D printing project shares successes

Product reduces TPH levels to non-hazardous status

November 27, 2024

Police ID man who died after Corso Italia fight

December 23, 2024

Hospital Mergers Fail to Deliver Better Care or Lower Costs, Study Finds todayheadline

December 31, 2024
Harris tells supporters 'never give up' and urges peaceful transfer of power

Harris tells supporters ‘never give up’ and urges peaceful transfer of power

0
Des Moines Man Accused Of Shooting Ex-Girlfriend's Mother

Des Moines Man Accused Of Shooting Ex-Girlfriend’s Mother

0

Trump ‘looks forward’ to White House meeting with Biden

0
Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

Catholic voters were critical to Donald Trump’s blowout victory: ‘Harris snubbed us’

0
As economic growth slows, Pacific Islands should boost women in jobs, says World Bank

As economic growth slows, Pacific Islands should boost women in jobs, says World Bank todayheadline

June 17, 2025
bar graph showing numbers neededto harm for one intracranial meningioma requiring surgery, according to progesterone use. desogestrel is above 60,000, while all other pills are less than 10,000.

Long-Term Contraceptive Pill Use Linked With Brain Tumor Risk : ScienceAlert todayheadline

June 17, 2025
Crews battle pair of fires in Ventura County

Crews battle pair of fires in Ventura County

June 17, 2025
When can the U.S. President deploy military on U.S. soil? | Explained

When can the U.S. President deploy military on U.S. soil? | Explained

June 17, 2025

Recent News

As economic growth slows, Pacific Islands should boost women in jobs, says World Bank

As economic growth slows, Pacific Islands should boost women in jobs, says World Bank todayheadline

June 17, 2025
3
bar graph showing numbers neededto harm for one intracranial meningioma requiring surgery, according to progesterone use. desogestrel is above 60,000, while all other pills are less than 10,000.

Long-Term Contraceptive Pill Use Linked With Brain Tumor Risk : ScienceAlert todayheadline

June 17, 2025
5
Crews battle pair of fires in Ventura County

Crews battle pair of fires in Ventura County

June 17, 2025
8
When can the U.S. President deploy military on U.S. soil? | Explained

When can the U.S. President deploy military on U.S. soil? | Explained

June 17, 2025
3

TodayHeadline is a dynamic news website dedicated to delivering up-to-date and comprehensive news coverage from around the globe.

Follow Us

Browse by Category

  • Africa
  • Asia
  • Basketball
  • Business & Finance
  • Climate Change
  • Crime & Justice
  • Cybersecurity
  • Economic Policies
  • Elections
  • Entertainment
  • Entrepreneurship
  • Environmental Policies
  • Europe
  • Football
  • Gadgets & Devices
  • Health
  • Medical Research
  • Mental Health
  • Middle East
  • Motorsport
  • Olympics
  • Politics
  • Public Health
  • Relationships & Family
  • Science & Environment
  • Software & Apps
  • Space Exploration
  • Sports
  • Stock Market
  • Technology & Startups
  • Tennis
  • Travel
  • Uncategorized
  • Us & Canada
  • Wildlife & Conservation
  • World News

Recent News

As economic growth slows, Pacific Islands should boost women in jobs, says World Bank

As economic growth slows, Pacific Islands should boost women in jobs, says World Bank todayheadline

June 17, 2025
bar graph showing numbers neededto harm for one intracranial meningioma requiring surgery, according to progesterone use. desogestrel is above 60,000, while all other pills are less than 10,000.

Long-Term Contraceptive Pill Use Linked With Brain Tumor Risk : ScienceAlert todayheadline

June 17, 2025
  • Education
  • Lifestyle
  • Technology & Startups
  • About us
  • Contact
  • Advertise with Us
  • Privacy & Policy

© 2024 Todayheadline.co

Welcome Back!

OR

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Business & Finance
  • Corporate News
  • Economic Policies
  • Entrepreneurship
  • Market Trends
  • Crime & Justice
  • Court Cases
  • Criminal Investigations
  • Cybercrime
  • Legal Reforms
  • Policing
  • Education
  • Higher Education
  • Online Learning
  • Entertainment
  • Awards & Festivals
  • Celebrity News
  • Movies
  • Music
  • Health
  • Fitness & Nutrition
  • Medical Breakthroughs
  • Mental Health
  • Pandemic Updates
  • Lifestyle
  • Fashion & Beauty
  • Food & Drink
  • Home & Living
  • Politics
  • Elections
  • Government Policies
  • International Relations
  • Legislative News
  • Political Parties
  • Africa
  • Asia
  • Europe
  • Middle East
  • Artificial Intelligence
  • Cybersecurity
  • Emerging Technologies
  • Gadgets & Devices
  • Industry Analysis
  • Basketball
  • Football
  • Motorsport
  • Olympics
  • Climate Change
  • Environmental Policies
  • Medical Research
  • Science & Environment
  • Space Exploration
  • Wildlife & Conservation
  • Sports
  • Tennis
  • Technology & Startups
  • Software & Apps
  • Startup Success Stories
  • Startups & Innovations
  • Tech Regulations
  • Venture Capital
  • Uncategorized
  • World News
  • Us & Canada
  • Public Health
  • Relationships & Family
  • Travel
  • Research & Innovation
  • Scholarships & Grants
  • School Reforms
  • Stock Market
  • TV & Streaming
  • Advertise with Us
  • Privacy & Policy
  • About us
  • Contact

© 2024 Todayheadline.co