The global average for countries to report genetic information about bird flu, crucial to tracking and preventing a human pandemic, was seven months, and Canada came in last, a new study has found.
Authors of the non-peer reviewed commentary published today in Nature Biotechnology say the work highlights the urgent need for Canada and other countries to speed up the pipeline from sampling an infected creature, analysis of the genetic information, and submission to a global scientific database.
Dr. Sarah Otto (SO), professor in the department of zoology, and Sean Edgerton (SE) (he/him), zoology doctoral student, discuss why getting this information quickly is crucial, and how Canada has pulled its socks up once before.
Why do we need this data?
SO: We need to track the evolution of viruses if we are to have any hope of preventing another pandemic. The particular flu strain we’re worried about, H5N1, has wreaked havoc on the dairy and poultry industry in several countries and spread to hundreds of species of birds and mammals, but so far, the virus has not evolved the features needed to spread efficiently among humans. With real-time genetic data being submitted from around the world, we can keep an eye on these features and, if we see this evolution, raise the alarm.
We did this with the COVID variants. By tracking the virus’s evolution through genetic data, we were able to provide advanced warnings about the spread of variants, allowing public health responses such as increasing hospital capacity and quickly offering vaccines to those most at risk. Together, we saved lives.
What did you find?
SE: We looked at close to 19,000 H5N1 samples from January 2021 to December 2024 on a global database, the Global Initiative for Sharing All Influenza Data (GISAID). We measured the time taken from when a sample of the virus was collected from an animal or human through analysis of the genetic data to submission to this database, where it’s then available for other scientists to study. We then calculated the average per country submitting at least 50 sequences. We found the global average was about 228 days. Canada was the slowest at 618 days on average. The fastest countries were the Czech Republic and the Netherlands at only 25 days on average.
It was a bit shocking how long it took especially for a virus with pandemic potential like H5N1.
Why are the delays this long?
SO: We’re not sure, but the delays could be due to the number of different institutions involved in the entire collection, analysis, and submission process. In addition, there is little targeted funding to monitor H5N1 in Canadian wildlife, so most efforts to monitor the spread of this highly pathogenic flu virus are piggy-backing on other studies.
What can we do?
SO: I know we can get better. Canada improved submission times dramatically for SARS-CoV-2, dropping data delays from about 88 days to 16. Canada is now one of the strongest and most efficient countries informing the world about changes to the virus that causes COVID-19. We can do the same with H5N1.
We are also concerned about recent restrictions on gathering and sharing information in the United States, with widespread firing of government scientists and restrictions on data sharing. Wildlife don’t care about borders, so Canada needs to step up to the plate and monitor what’s happening in North America to help alert ourselves and other countries to worrisome changes in this virus.
More information:
Sarah P. Otto et al, Lengthy delays in H5N1 genome submissions to GISAID, Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02636-6
Citation:
Q&A: Canada slowest in reporting bird flu at 618 days—but past COVID response shows potential for improvement (2025, March 25)
retrieved 25 March 2025
from https://medicalxpress.com/news/2025-03-qa-canada-slowest-bird-flu.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
The global average for countries to report genetic information about bird flu, crucial to tracking and preventing a human pandemic, was seven months, and Canada came in last, a new study has found. Authors of the non-peer reviewed commentary published today in Nature Biotechnology say the work highlights the urgent need for Canada and other countries to speed up the pipeline from sampling an infected creature, analysis of the genetic information, and submission to a global scientific database. Dr. Sarah Otto (SO), professor in the department of zoology, and Sean Edgerton (SE) (he/him), zoology doctoral student, discuss why getting this information quickly is crucial, and how Canada has pulled its socks up once before. SO: We need to track the evolution of viruses if we are to have any hope of preventing another pandemic. The particular flu strain we’re worried about, H5N1, has wreaked havoc on the dairy and poultry industry in several countries and spread to hundreds of species of birds and mammals, but so far, the virus has not evolved the features needed to spread efficiently among humans. With real-time genetic data being submitted from around the world, we can keep an eye on these features and, if we see this evolution, raise the alarm. We did this with the COVID variants. By tracking the virus’s evolution through genetic data, we were able to provide advanced warnings about the spread of variants, allowing public health responses such as increasing hospital capacity and quickly offering vaccines to those most at risk. Together, we saved lives. SE: We looked at close to 19,000 H5N1 samples from January 2021 to December 2024 on a global database, the Global Initiative for Sharing All Influenza Data (GISAID). We measured the time taken from when a sample of the virus was collected from an animal or human through analysis of the genetic data to submission to this database, where it’s then available for other scientists to study. We then calculated the average per country submitting at least 50 sequences. We found the global average was about 228 days. Canada was the slowest at 618 days on average. The fastest countries were the Czech Republic and the Netherlands at only 25 days on average. It was a bit shocking how long it took especially for a virus with pandemic potential like H5N1. SO: We’re not sure, but the delays could be due to the number of different institutions involved in the entire collection, analysis, and submission process. In addition, there is little targeted funding to monitor H5N1 in Canadian wildlife, so most efforts to monitor the spread of this highly pathogenic flu virus are piggy-backing on other studies. SO: I know we can get better. Canada improved submission times dramatically for SARS-CoV-2, dropping data delays from about 88 days to 16. Canada is now one of the strongest and most efficient countries informing the world about changes to the virus that causes COVID-19. We can do the same with H5N1. We are also concerned about recent restrictions on gathering and sharing information in the United States, with widespread firing of government scientists and restrictions on data sharing. Wildlife don’t care about borders, so Canada needs to step up to the plate and monitor what’s happening in North America to help alert ourselves and other countries to worrisome changes in this virus. More information: Citation: This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
Why do we need this data?
What did you find?
Why are the delays this long?
What can we do?
Sarah P. Otto et al, Lengthy delays in H5N1 genome submissions to GISAID, Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02636-6
Q&A: Canada slowest in reporting bird flu at 618 days—but past COVID response shows potential for improvement (2025, March 25)
retrieved 25 March 2025
from https://medicalxpress.com/news/2025-03-qa-canada-slowest-bird-flu.html
part may be reproduced without the written permission. The content is provided for information purposes only.
