Low LDL cholesterol levels linked to reduced risk of dementia

People with low levels of low-density lipoprotein cholesterol (LDL-C) in their blood have a lower risk of dementia, including lower risk of Alzheimer’s disease-related dementia, shows a study published online in the Journal of Neurology Neurosurgery & Psychiatry.

Use of statins conveyed an additional protective effect for people with low LDL-C, specifically those with blood levels less than 1.8 mmol/L (

However, reducing LDL-C to very low levels below 0.8 mmol/L (

The benefits of low LDL-C levels to protect against cardiovascular events is well recognized, but the relationship between LDL-C levels and dementia has been less clear, particularly the cut-off for LDL-C below which there is no further benefit for reducing risk of cognitive decline.

To address this, the authors accessed data collected by 11 university hospitals on adult outpatients with no previous diagnosis of dementia followed for at least 180 days after LDL-C testing. They identified 192,213 people with LDL-C levels less than 1.8 mmol/L (130mg/dL), and matched individuals in each group into 108,980 matched pairs.

Analysis of subsequent diagnoses of dementia showed that LDL-C levels below 1.8 mmol/L (130mg/dL).

The protective effect against cognitive decline lessened at lower LDL-C levels and eventually disappeared entirely. At LDL-C levels below 1.4 mmol/L (130mg/dL), and when LDL-C levels fell below 0.8 mmol/L (

Statin use conferred additional protection against dementia in the presence of low LDL-C levels. Among people with LDL-C levels below 1.8 mmol/L (

This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. The authors also acknowledge that the study has some limitations, including the potential for unmeasured confounding factors because of its retrospective design, possible underreporting of dementia cases due to variations in diagnostic accuracy between hospitals, and the focus on baseline LDL-C levels when lipid profiles could change over time.

Nevertheless, the authors conclude, “Low LDL-C levels (disease-related dementia, with statin therapy providing additional protective effects.”

They add, “These findings underscore the crucial role of managing LDL-C in lowering dementia risk.”

People with low levels of low-density lipoprotein cholesterol (LDL-C) in their blood have a lower risk of dementia, including lower risk of Alzheimer’s disease-related dementia, shows a study published online in the Journal of Neurology Neurosurgery & Psychiatry.

Use of statins conveyed an additional protective effect for people with low LDL-C, specifically those with blood levels less than 1.8 mmol/L (

However, reducing LDL-C to very low levels below 0.8 mmol/L (

The benefits of low LDL-C levels to protect against cardiovascular events is well recognized, but the relationship between LDL-C levels and dementia has been less clear, particularly the cut-off for LDL-C below which there is no further benefit for reducing risk of cognitive decline.

To address this, the authors accessed data collected by 11 university hospitals on adult outpatients with no previous diagnosis of dementia followed for at least 180 days after LDL-C testing. They identified 192,213 people with LDL-C levels less than 1.8 mmol/L (130mg/dL), and matched individuals in each group into 108,980 matched pairs.

Analysis of subsequent diagnoses of dementia showed that LDL-C levels below 1.8 mmol/L (130mg/dL).

The protective effect against cognitive decline lessened at lower LDL-C levels and eventually disappeared entirely. At LDL-C levels below 1.4 mmol/L (130mg/dL), and when LDL-C levels fell below 0.8 mmol/L (

Statin use conferred additional protection against dementia in the presence of low LDL-C levels. Among people with LDL-C levels below 1.8 mmol/L (

This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. The authors also acknowledge that the study has some limitations, including the potential for unmeasured confounding factors because of its retrospective design, possible underreporting of dementia cases due to variations in diagnostic accuracy between hospitals, and the focus on baseline LDL-C levels when lipid profiles could change over time.

Nevertheless, the authors conclude, “Low LDL-C levels (disease-related dementia, with statin therapy providing additional protective effects.”

They add, “These findings underscore the crucial role of managing LDL-C in lowering dementia risk.”