About a million Americans a year are expected to develop dementia by 2060, roughly double today’s toll, researchers reported Monday.
That estimate is based on a new study that found a higher lifetime risk than previously thought: After age 55, people have up to a 4 in 10 chance of eventually developing dementia—if they live long enough.
It’s a sobering number but there are steps people can take to reduce that risk, such as controlling high blood pressure and other bad-for-the-brain health problems. And it’s not too late to try even in middle age.
“All of our research suggests what you do in midlife really matters,” said Dr. Josef Coresh of NYU Langone Health, who coauthored the study in the journal Nature Medicine.
Dementia isn’t only Alzheimer’s
Taking longer to recall a name or where you put your keys is typical with older age. But dementia isn’t a normal part of aging—it’s a progressive loss of memory, language and other cognitive functions. Simply getting older is the biggest risk and the population is rapidly aging.
Alzheimer’s is the most common form, and silent brain changes that eventually lead to it can begin two decades before symptoms appear. Other types include vascular dementia, when heart disease or small strokes impair blood flow to the brain. Many people have mixed causes, meaning vascular problems could exacerbate brewing Alzheimer’s symptoms.
Measuring the risk from a certain age over the potential remaining life span can guide public health recommendations and medical research.
“It’s not a guarantee that someone will develop dementia,” cautioned Dr. James Galvin, a University of Miami Alzheimer’s specialist. He wasn’t involved with the new study but said the findings fit with other research.
Dementia risk is different by age
Prior studies estimated about 14% of men and 23% of women would develop some form of dementia during their lifetime. Coresh’s team analyzed more recent data from a U.S. study that has tracked the heart health and cognitive function of about 15,000 older adults for several decades.
Importantly, they found the risk changes with the decades.
Only 4% of people developed dementia between the ages of 55 and 75, what Coresh calls a key 20-year window for protecting brain health.
For people who survive common health threats until 75, the dementia risk then jumped—to 20% by age 85 and 42% between ages 85 and 95.
Overall, the lifetime dementia risk after age 55 was 35% for men and 48% for women, the researchers concluded. Women generally live longer than men, a main reason for that difference, Coresh noted. Black Americans had a slightly higher risk, 44%, than white people at 41%.
Yes, there are ways to help lower dementia risk
There are some risk factors people can’t control, including age and whether you inherited a gene variant called APOE4 that raises the chances of late-in-life Alzheimer’s.
But people can try to avert or at least delay health problems that contribute to later dementia. Coresh, for example, wears a helmet when biking because repeated or severe brain injuries from crashes or falls increase the risk of later-in-life dementia.
Especially important: “What’s good for your heart is good for your brain,” added Miami’s Galvin. He urges people to exercise, avoid obesity, and control blood pressure, diabetes and cholesterol.
For example, high blood pressure can impair blood flow to the brain, a risk not just for vascular dementia but also linked to some hallmarks of Alzheimer’s. Similarly, the high blood sugar of poorly controlled diabetes is linked to cognitive decline and damaging inflammation in the brain.
Stay socially and cognitively active, too, Galvin said. He urges people to try hearing aids if age brings hearing loss, which can spur social isolation.
“There are things that we have control over, and those things I think would be really, really important to build a better brain as we age,” he said.
More information:
Michael Fang et al, Lifetime risk and projected burden of dementia, Nature Medicine (2025). DOI: 10.1038/s41591-024-03340-9
© 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.
Citation:
Up to 4 in 10 people could develop dementia after 55. What you can do to lower your risk (2025, January 14)
retrieved 14 January 2025
from https://medicalxpress.com/news/2025-01-longer-dementia-ways.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
About a million Americans a year are expected to develop dementia by 2060, roughly double today’s toll, researchers reported Monday. That estimate is based on a new study that found a higher lifetime risk than previously thought: After age 55, people have up to a 4 in 10 chance of eventually developing dementia—if they live long enough. It’s a sobering number but there are steps people can take to reduce that risk, such as controlling high blood pressure and other bad-for-the-brain health problems. And it’s not too late to try even in middle age. “All of our research suggests what you do in midlife really matters,” said Dr. Josef Coresh of NYU Langone Health, who coauthored the study in the journal Nature Medicine. Taking longer to recall a name or where you put your keys is typical with older age. But dementia isn’t a normal part of aging—it’s a progressive loss of memory, language and other cognitive functions. Simply getting older is the biggest risk and the population is rapidly aging. Alzheimer’s is the most common form, and silent brain changes that eventually lead to it can begin two decades before symptoms appear. Other types include vascular dementia, when heart disease or small strokes impair blood flow to the brain. Many people have mixed causes, meaning vascular problems could exacerbate brewing Alzheimer’s symptoms. Measuring the risk from a certain age over the potential remaining life span can guide public health recommendations and medical research. “It’s not a guarantee that someone will develop dementia,” cautioned Dr. James Galvin, a University of Miami Alzheimer’s specialist. He wasn’t involved with the new study but said the findings fit with other research. Prior studies estimated about 14% of men and 23% of women would develop some form of dementia during their lifetime. Coresh’s team analyzed more recent data from a U.S. study that has tracked the heart health and cognitive function of about 15,000 older adults for several decades. Importantly, they found the risk changes with the decades. Only 4% of people developed dementia between the ages of 55 and 75, what Coresh calls a key 20-year window for protecting brain health. For people who survive common health threats until 75, the dementia risk then jumped—to 20% by age 85 and 42% between ages 85 and 95. Overall, the lifetime dementia risk after age 55 was 35% for men and 48% for women, the researchers concluded. Women generally live longer than men, a main reason for that difference, Coresh noted. Black Americans had a slightly higher risk, 44%, than white people at 41%. There are some risk factors people can’t control, including age and whether you inherited a gene variant called APOE4 that raises the chances of late-in-life Alzheimer’s. But people can try to avert or at least delay health problems that contribute to later dementia. Coresh, for example, wears a helmet when biking because repeated or severe brain injuries from crashes or falls increase the risk of later-in-life dementia. Especially important: “What’s good for your heart is good for your brain,” added Miami’s Galvin. He urges people to exercise, avoid obesity, and control blood pressure, diabetes and cholesterol. For example, high blood pressure can impair blood flow to the brain, a risk not just for vascular dementia but also linked to some hallmarks of Alzheimer’s. Similarly, the high blood sugar of poorly controlled diabetes is linked to cognitive decline and damaging inflammation in the brain. Stay socially and cognitively active, too, Galvin said. He urges people to try hearing aids if age brings hearing loss, which can spur social isolation. “There are things that we have control over, and those things I think would be really, really important to build a better brain as we age,” he said. More information: © 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. Citation: This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
Dementia isn’t only Alzheimer’s
Dementia risk is different by age
Yes, there are ways to help lower dementia risk
Michael Fang et al, Lifetime risk and projected burden of dementia, Nature Medicine (2025). DOI: 10.1038/s41591-024-03340-9
Up to 4 in 10 people could develop dementia after 55. What you can do to lower your risk (2025, January 14)
retrieved 14 January 2025
from https://medicalxpress.com/news/2025-01-longer-dementia-ways.html
part may be reproduced without the written permission. The content is provided for information purposes only.
